A cytosolic NAD-dependent deacetylase, Hst2p, can modulate . . . - scite Supporting: 10, Contrasting: 4, Mentioning: 134 - In budding yeast, the silent information regulator Sir2p is a nuclear NAD-dependent deacetylase that is essential for both telomeric and rDNA silencing All eukaryotic species examined to date have multiple homologues of Sir two (HSTs), which share a highly conserved globular core domain Here we report that yeast Hst2p and a mammalian Hst2p
The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin . . . The silent information regulator 2 protein (Sir2p) of Saccharomyces cerevisiae is an NAD-dependent histone deacetylase that plays a critical role in transcriptional silencing Here, we report that a human ortholog of Sir2p, sirtuin type 2 (SIRT2), is a predominantly cytoplasmic protein that colocali …
A cytosolic NAD-dependent deacetylase, Hst2p, can modulate nucleolar . . . In budding yeast, the silent information regulator Sir2p is a nuclear NAD-dependent deacetylase that is essential for both telomeric and rDNA silencing All eukaryotic species examined to date have multiple homologues of Sir two (HSTs), which share a highly conserved globular core domain Here we
NAD+-Dependent Deacetylase Hst1p Controls Biosynthesis and Cellular . . . Bacterially expressed and purified GST-Hst1p, GST-Hst2p, and GST-Sir2p proteins were incubated with chemically [3 H]acetylated histone H4 peptide (40,000 cpm reaction mixture) and different concentrations of NAD + NAD +-dependent deacetylase activity, normalized for the V max of each protein, is plotted
Serval - A cytosolic NAD-dependent deacetylase, Hst2p, can modulate . . . In budding yeast, the silent information regulator Sir2p is a nuclear NAD-dependent deacetylase that is essential for both telomeric and rDNA silencing All eukaryotic species examined to date have multiple homologues of Sir two (HSTs), which share a highly conserved globular core domain Here we report that yeast Hst2p and a mammalian Hst2p homologue, hSirT2p, are cytoplasmic in yeast and
A cytosolic NAD‐dependent deacetylase, Hst2p, can modulate nucleolar . . . In budding yeast, the s ilent i nformation r egulator Sir2p is a nuclear NAD‐dependent deacetylase that is essential for both telomeric and rDNA silencing All eukaryotic species examined to date have multiple h omologues of S ir t wo (HSTs), which share a highly conserved globular core domain Here we report that yeast Hst2p and a mammalian Hst2p homologue, hSirT2p, are cytoplasmic in yeast