Transmembrane activator and CAML interactor - Wikipedia TACI is a lymphocyte-specific member of the tumor necrosis factor (TNF) receptor superfamily It was originally discovered because of its ability to interact with calcium-modulator and cyclophilin ligand (CAML)
TACI, an enigmatic BAFF APRIL receptor, with new . . . The discovery of TACI mutations associated with common variable immunodeficiency (CVID) in humans not only reinforces its important role for humoral responses but also suggests a more complex role than first anticipated from knockout animals
TACI deficiency — a complex system out of balance TACI promotes T-cell independent antibody responses and plasma cell differentiation and counteracts BAFF driven B-cell activation Mutations in TNFRSF13B (encoding TACI) are associated with common variable immunodeficiency (CVID) but are also found in 1–2% of the general population
Atacicept in IgAN - Vera Therapeutics Multinational, randomized, double-blind, placebo-controlled Phase 3 clinical trial evaluating the safety and efficacy of atacicept 150 mg in adults with IgAN who continue to have persistent proteinuria and remain at high risk of disease progression
Ligand-independent oligomerization of TACI is controlled by . . . TACI (transmembrane activator and calcium modulator and cyclophilin ligand interactor) is a TNF receptor superfamily member that binds the ligands BAFF (B cell activation factor of the TNF family, BLyS) and APRIL (a proliferation-inducing ligand) (Bodmer et al , 2002; Mackay and Schneider, 2009)
TACI in Immunochemistry: A Comprehensive Guide TACI, or Transmembrane Activator and CAML Interactor, is a receptor that plays a crucial role in the regulation of the immune system Understanding TACI is essential for grasping its significance in immunochemistry and its potential applications in research and therapy