Transmembrane activator and CAML interactor - Wikipedia Transmembrane activator and CAML interactor (TACI), also known as tumor necrosis factor receptor superfamily member 13B (TNFRSF13B) is a protein that in humans is encoded by the TNFRSF13B gene
TACI, an enigmatic BAFF APRIL receptor, with new . . . - PubMed The discovery of TACI mutations associated with common variable immunodeficiency (CVID) in humans not only reinforces its important role for humoral responses but also suggests a more complex role than first anticipated from knockout animals TACI is emerging as an unusual TNF receptor-like molecule with a sophisticated mode of action
TACI mutations and disease susceptibility in patients with . . . The most prevalent primary immunodeficiency is common variable immunodeficiency (CVID) Mutations have been described in four genes, ICOS, CD19, BAFF-R and TNFRSF13B (encoding TACI), together associated with 10–15% of CVID cases We investigated a
Ligand-independent oligomerization of TACI is controlled by . . . TACI (transmembrane activator and calcium modulator and cyclophilin ligand interactor) is a TNF receptor superfamily member that binds the ligands BAFF (B cell activation factor of the TNF family, BLyS) and APRIL (a proliferation-inducing ligand) (Bodmer et al , 2002; Mackay and Schneider, 2009)
TNFRSF13B gene: MedlinePlus Genetics The TNFRSF13B gene provides instructions for making a protein called TACI The TACI protein is found on the surface of immune system cells called B cells These specialized white blood cells help protect the body against infection from foreign invaders such as bacteria and viruses
Total anterior circulation infarct - Wikipedia Total anterior circulation infarct (TACI) is a type of cerebral infarction affecting the entire anterior circulation supplying one side of the brain The anterior circulation is the part that is supplied by the internal carotid artery, as opposed to the posterior circulation, supplied by the vertebral arteries
Effect of TACI Signaling on Humoral Immunity and Autoimmune . . . Transmembrane activator and calcium-modulating cyclophilin ligand interactor (TACI) is one of the receptors of B cell activating factor of the tumor necrosis factor family (BAFF) and a proliferation-inducing ligand (APRIL) TACI is a regulator in the immune responses
TACI and endogenous APRIL in B cell maturation - ScienceDirect Here we show that the expression of intracellular TACI-S increases with B cell activation, and colocalizes with BCMA and their ligand, APRIL We show that the loss of APRIL impairs isotype class switch and leads to distinct metabolic and transcriptional changes