Immune-mediated strategies to solving the HIV reservoir problem Here, we summarize the key scientific evidence supporting the hypothesis that host immune responses, including those mediated by CD8 + T cells, B cells, antibodies and innate immune cells, affect the size, clonality, and cellular, tissue and organ distribution of the HIV reservoir
The Biology of the HIV-1 Latent Reservoir and Implications for Cure . . . In this review, we discuss how the reservoir is maintained during ART, where the virus resides during treatment, how gender, age and other parameters affect the reservoir, and finally how knowledge of these factors might lead to effective interventions
Immune-mediated strategies to solving the HIV reservoir problem Here, we summarize the key scientific evidence supporting the hypothesis that host immune responses, including those mediated by CD8 + T cells, B cells, antibodies and innate immune cells,
HIV reservoirs: what, where and how to target them. One of the main challenges in the fight against HIV infection is to develop strategies that are able to eliminate the persistent viral reservoir that harbours integrated, replication-competent provirus within host cellular DNA
What Is the Viral Reservoir, and Why Does It Matter? - TheBody “However, recent studies, using new high-resolution technologies, have challenged this view and observed some [specific] footprints of immune-system action against reservoir cells, implying
Reservoir Host Immune Responses to Emerging Zoonotic Viruses Immunological studies investigating quantitative and qualitative differences in the host-virus equilibrium in animal reservoirs will be key to answering this question, informing new approaches for treating and preventing zoonotic diseases
How Does the HIV Reservoir Avoid Destruction? ADCC appears to be an important component of the immune system’s attempts to suppress HIV reservoirs, whose persistence despite antiretroviral therapy is the main barrier to a cure However, the susceptibility of HIV-infected cells to ADCC depends on two key factors
Targeting the Latent Reservoir for HIV-1 - Cell Press Developing a cure for HIV-1 requires understanding the mechanisms of HIV-1 persistence in the latent reservoir In this review, we discuss historical and recent paradigms in the HIV-1 persistence field as well as novel immunologic and pharmacologic strategies for eliminating this reservoir
Barriers for HIV Cure: The Latent Reservoir - PMC - PubMed Central (PMC) In this review, we discuss advances in the field that have allowed a better understanding of HIV-1 latency, including the diverse cell types that constitute the latent reservoir, factors influencing latency, tools to study HIV-1 latency, as well as current and prospective therapeutic approaches to target these latently infected cells, so a funct
HIV reservoirs: what, where and how to target them - PubMed One of the main challenges in the fight against HIV infection is to develop strategies that are able to eliminate the persistent viral reservoir that harbours integrated, replication-competent provirus within host cellular DNA
Local immune activation shapes systemic HIV reservoirs In a person living with with human immunodeficiency virus (HIV), the recruitment of CD4 + T cells that recognize a co-pathogen in the central nervous system (CNS) resulted in localized
Recent progress in understanding HIV reservoirs - PMC Reservoirs of HIV-1-infected cells persist long-term despite highly effective antiretroviral suppression therapy and represent the main barrier against a cure for HIV-1 This review summarizes recent advances in understanding the complexity and diversity of viral reservoir cells