Cytokine Dynamics During Ustekinumab Induction as Predictors of . . . Overall, UST induction was associated with a global decrease in proinflammatory cytokines, particularly TNF-α and IL-1β Responders displayed distinct cytokine patterns, with higher IL-13 levels at week 8 and lower IL-8 concentrations at week 16 compared with non-responders
Pro-Inflammatory Cytokines Underlying the Inflammation of Crohn’s . . . The purpose of this review is to encapsulate our current understanding of the pro-inflammatory cytokines responsible for the inflammation underlying Crohn’s disease and the prospect of using this information to devise therapy for this condition based on inhibition of these cytokines
Crohn’s Disease and Ulcerative Colitis Show Unique Cytokine Profiles Networks of cytokines have been implicated in both forms of inflammatory bowel disease (IBD): Crohn’s disease (CD) and ulcerative colitis (UC) While CD has associated with T-helper type 1 (Th1) immune responses, UC shows Th2 patterns
Cytokine Therapies in Crohns Disease: Where are We Now and where should . . . Indeed, cytokine blockers, including the three licensed anti- TNF-α and the neutralizing IL-12 p40 antibodies, have already been tested with success in CD More than one third of patients do not respond to these treatments and response can wane with time
Cytokine therapy for Crohns disease: advances in translational . . . This review discusses novel concepts in CD pathogenesis and the roles of cytokines in the initiation and perpetuation of disease In addition, we review applications of cytokine-based therapies in human clinical trials and preclinical animal studies