Mannitol-induced acute renal failure - The American Journal . . . Mannitol is an osmotic diuretic used in various clinical settings, including brain edema, glaucoma, and acute renal failure (1) A variety of complications associated with mannitol therapy can occur, such as volume depletion and hypernatremia due to lack of replacement, volume expansion, hyponatremia with high-dose infusion, and hyperkalemia by solvent drag Patients with marked mannitol
Mannitol Side Effects: Common, Severe, Long Term - Drugs. com Other side effects have included dryness of mouth, thirst, edema, arm pain, chills, dehydration, fever, mannitol intoxication, and angina-like pain Eight cases of mannitol IV overdose in patients with preexisting renal failure were reviewed Symptoms presented in the reviewed cases were CNS involvement out of proportion to uremia, severe
Intravascular Administration of Mannitol for Acute Kidney . . . The diuretic effect of mannitol in these non-AKI risk patients was affirmed (although the benefit of its clinical use in decreasing the intracranial pressure is under estimation) [38] , [39] But according to the results of the present study, the diuretic effect of mannitol was significantly weakened in the patients with increased risk of AKI
Systematic Review of the Role of Mannitol in Renal Diseases Fang et al retrospectively studied a random cohort of 171 patients with cerebral trauma to investigate the risk factors of AKI following cerebral trauma, and found that the accumulative doses of mannitol were independent risk factors of AKI ARF induced by mannitol is a lethal adverse effect, and hemodialysis or plasma exchange is recommended
mannitol injection, USP Warnings and Precautions Patient . . . Patients with oliguric acute kidney injury who subsequently develop anuria while receiving mannitol are at risk of congestive heart failure, pulmonary edema, hypertensive crisis, coma, and death During and following infusion of Mannitol Injection for the reduction in intracranial pressure, monitor the patient clinically and laboratory tests