Environmentally Not So Friendly: Global Warming, Air Pollution, and . . . Environmental stresses are increasingly recognized as significant risk factors for adverse health outcomes In particular, various forms of pollution and climate change are playing a growing role in promoting noncommunicable diseases, especially cardiovascular disease Given recent trends, global warming and air pollution are now associated with substantial cardiovascular morbidity and mortality
Pathogenic mutations and overall survival in 3,084 patients with cancer . . . Background: We evaluated the association between pathogenic mutations and overall survival (OS) in patients with cancer referred to Hellenic Cooperative Oncology Group-affiliated Departments Patients and methods: Patients referred from 12 1980 to 1 2017 had molecular testing (for research) of archival tumor tissue collected at the time of first diagnosis (non-metastatic, 81%; metastatic, 19%)
Evaluating the Effectiveness of an Online Cardiac Rehabilitation . . . BACKGROUND: Cardiac rehabilitation (CR) is an important tool for the secondary prevention of cardiac disease Despite its proven effectiveness, CR remains vastly under-utilised especially amongst the most disadvantaged patients As an adjunct to CR, the St Vincent's Heart Health website (SVHHH) was created by the St Vincent's Hospital CR team to provide information via simplified medical text
An alternans way to quantify arrhythmogenic substrates. Vandenberg, Jamie I and Hill, Adam P (2016) An 'alternans' way to quantify arrhythmogenic substrates The Journal of Physiology, 594 (9) pp 2375-6 ISSN 1469-7793 (PMC OA) Full text not available from this repository
The New South Wales Sudden Cardiac Arrest Registry: A Data Linkage . . . BACKGROUND: Sudden cardiac arrest (SCA) in young people aged 1 to 50 years often occurs with no presenting symptoms or risk factors prompting screening for cardiovascular disease prior to their cardiac arrest Approximately 3,000 young Australians suffer from sudden cardiac death (SCD) each year, making this a major public health issue However, there is significant variation in the way
A mitochondrial cytopathy presenting with persistent troponin elevation . . . BACKGROUND: Mitochondrial diseases represent an important potential cause of cardiomyopathy and should be considered in patients presenting with multisystem manifestations Timely diagnosis of a mitochondrial disorder is needed as it can have reproductive implications for the offspring of the proband CASE SUMMARY: We describe a case of undifferentiated rising and persistent troponin elevation
Longitudinal analysis left ventricular chamber responses under durable . . . Gunawan, Aaron and Robson, Desiree and Krishnaswamy, Rohan J and Ramanayake, Anju and Kearney, Katherine and Muthiah, Kavitha and Jain, Pankaj and Adji, Audrey and Hayward, Christopher S (2024) Longitudinal analysis left ventricular chamber responses under durable LVAD support The Journal of Heart and Lung Transplantation, 43 (3) pp 420-431 ISSN 10532498
Association of the PHACTR1 EDN1 Genetic Locus With Spontaneous Coronary . . . BACKGROUND: Spontaneous coronary artery dissection (SCAD) is an increasingly recognized cause of acute coronary syndromes (ACS) afflicting predominantly younger to middle-aged women Observational studies have reported a high prevalence of extracoronary vascular anomalies, especially fibromuscular dysplasia (FMD) and a low prevalence of coincidental cases of atherosclerosis
Action Potential Morphology Accurately Predicts Proarrhythmic Risk for . . . Lee, William and Ng, Ben and Mangala, Melissa M and Perry, Matthew D and Subbiah, Rajesh N and Vandenberg, Jamie I and Hill, Adam P (2023) Action Potential Morphology Accurately Predicts Proarrhythmic Risk for Drugs With Potential to Prolong Cardiac Repolarization Circulation: Arrhythmia and Electrophysiology, 16 (7) pp 399-410 ISSN 1941-3149
Portopulmonary Hypertension: The Interplay Between the Liver and . . . Bart, Nicole K and Liu, Ken and Kotlyar, Eugene and Keogh, Anne M (2022) Portopulmonary Hypertension: The Interplay Between the Liver and Pulmonary Arteries Heart, Lung and Circulation, 31 (9) pp 1185-1187 ISSN 14439506 Full text not available from this repository
Human Induced Pluripotent Stem Cells as a Model of Complex Cardiac . . . Hypoplastic left heart (HLH) is a genetically complex disease, characterized by hypoplasia of the left side of the heart Although it is one of the most severe forms of congenital heart defects, our current knowledge of the molecular underpinnings of the disease is very limited Here, we have generated an in vitro model of HLH using human induced pluripotent stem cells (hiPSCs) to uncover
The bromodomains of BET family proteins can recognize diacetylated . . . Chemical modifications of histone tails influence genome accessibility and the transcriptional state of eukaryotic cells Lysine acetylation is one of the most common modifications and acetyllysine-binding bromodomains (BDs) provide a means for acetyllysine marks to be translated into meaningful cellular responses Here, we have investigated the mechanism underlying the reported association
Reduced connexin-43 expression, slow conduction and repolarisation . . . Hypertrophic cardiomyopathy (HCM) is an inherited heart muscle disease that is characterised by left ventricular wall thickening, cardiomyocyte disarray and fibrosis, and is associated with arrhythmias, heart failure and sudden death However, it is unclear to what extent the electrophysiological disturbances that lead to sudden death occur secondary to structural changes in the myocardium or
Characterization of Plasma Labile Heme in Hemolytic Conditions. Extracellular hemoglobin (Hb), a byproduct of hemolysis, can release its prosthetic heme groups upon oxidation This produces metabolically active heme that is exchangeable between acceptor proteins, macromolecules and low molecular weight ligands, termed here labile heme As it accumulates in plasma labile heme acts in a pro-oxidant manner and regulates cellular metabolism while exerting pro
Cis-acting variation is common across regulatory layers but is often . . . Floc'hlay, Swann and Wong, Emily S and Zhao, Bingqing and Viales, Rebecca R and Thomas-Chollier, Morgane and Thieffry, Denis and Garfield, David A and Furlong, Eileen E M (2021) Cis-acting variation is common across regulatory layers but is often buffered during embryonic development Genome Research, 31 (2) pp 211-224 ISSN 1088-9051