First-Line Treatment for Hypertension - AAFP Because the use of thiazide diuretics is supported by a strong body of evidence and no other class of antihypertensive medications has been shown to be better at improving outcomes, they are the
Antihypertensive Medications - StatPearls - NCBI Bookshelf Describe the guidelines for using antihypertensive medications and guide the treatment choices for first-line treatment Review the different anti-hypertensive medication classes, summarizing the guidelines for the indication to use combination treatment when mono-therapy fails
First‐line drugs for hypertension - PMC - PubMed Central (PMC) First‐line low‐dose thiazides reduced all morbidity and mortality outcomes in adult patients with moderate to severe primary hypertension First‐line ACE inhibitors and calcium channel blockers may be similarly effective, but the evidence was of lower quality
2017 Guideline for High Blood Pressure in Adults Initial first-line therapy for stage 1 hypertension includes thiazide diuretics, CCBs, and ACE inhibitors or ARBs Two first-line drugs of different classes are recommended with stage 2 hypertension and average BP of 20 10 mm Hg above the BP target
Comprehensive comparative effectiveness and safety of first-line . . . LEGEND-HTN is the largest and most comprehensive study ever conducted to provide evidence about the comparative effectiveness and safety of first-line antihypertensives, representing more than 4 9 million patients initiating monotherapy across nine databases from four countries, examining all pairwise comparisons between the five first-line
First-line drugs for hypertension - PubMed First-line low-dose thiazides reduced all morbidity and mortality outcomes in adult patients with moderate to severe primary hypertension First-line ACE inhibitors and calcium channel blockers may be similarly effective, but the evidence was of lower quality
First-line drugs for hypertension - PubMed Primary objective: To quantify the benefits and harms of the major first-line anti-hypertensive drug classes: thiazides, beta-blockers, calcium channel blockers, angiotensin converting enzyme (ACE) inhibitors, alpha-blockers, and angiotensin II receptor blockers (ARB)