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Guide for the Care and Use of Laboratory Animals, 8th edition. National . . . It was first published in 1963, under the title Guide for Laboratory Animal Facilities and Care, and was revised in 1965, 1968, 1972, 1978, 1985, and 1996 More than 550,000 copies have been printed since its first publication In 2006 an ad hoc committee appointed by the Institute for Laboratory Animal Research recommended that the Guide be