Vasomotion as a driving force for paravascular clearance in the awake . . . Van Veluw et al demonstrate that vasomotion is a major driving force for paravascular clearance of solutes from the brain Loss of vascular smooth muscle cells and reduced vasomotion in the context of amyloid deposition is associated with impaired clearance
Vasomotion Drives Periarterial Drainage of Aβ from the Brain In 14-month-old APP PS1 mice, vasomotion and clearance along the walls of arterioles were reduced This correlates with the age-related decrease in the number of arterial SMCs and not with the onset of CAA
Vasomotion as a Driving Force for Paravascular Clearance in the Awake . . . van Veluw et al demonstrate that vasomotion is a major driving force for paravascular clearance of solutes from the brain Loss of vascular smooth muscle cells and reduced vasomotion in the context of amyloid deposition is associated with impaired clearance
Vasomotion as a Driving Force for Paravascular Clearance in . . . - PubMed Paravascular drainage of solutes, including β-amyloid (Aβ), appears to be an important process in brain health and diseases such as Alzheimer's disease (AD) and cerebral amyloid angiopathy (CAA) However, the major driving force for clearance remains largely unknown
Is Vasomotion in Cerebral Arteries Impaired in Alzheimer’s Disease? Vasomotion produces diameter changes of comparable amplitude, however at lower rates, and could contribute to these mechanisms of Aβ clearance In spite of potential clinical interest, studies addressing cerebral vasomotion in the context of AD CAA are limited