Anti-Tumor Activity of Intravenously Administered Plumbagin Entrapped . . . Transferrin-bearing PEGylated PLGA nanoparticles entrapping plumbagin are therefore highly promising therapeutic systems, able to lead to tumor regression and even suppression after intravenous administration without visible toxicity
Anti-Tumor Activity of Intravenously Administered Plumbagin Entrapped . . . Plumbagin, a natural naphthoquinone from the officinal leadwort, has recently been shown to exert promising anti-cancer effects However, its therapeutic use is hampered by its failure to specifically reach tumors after intravenous administration, without secondary effects on normal tissues
Regression of Melanoma Following Intravenous Injection of Plumbagin . . . We have demonstrated for the first time that novel Tf-conjugated lipid–polymer hybrid nanoparticles loading plumbagin and administered intravenously resulted in a complete disappearance of 40% of B16-F10 melanoma tumors and regression of 10% of the tumors without any signs of animal distress
Anti-tumor activity of intravenously administered plumbagin entrapped . . . We hypothesize that the entrapment of plumbagin within PEGylated PLGA nanoparticles conjugated with transferrin, whose receptors are overexpressed on many types of cancer cells, could lead to a selective delivery of the drug to tumors following intravenous administration and enhance its chemotherapeutic effects
Synthesis, characterization, in-silico and in-vitro anticancer studies . . . In the present study, we have synthesized Plumbagin loaded Bovine Serum Albumin nanoparticles to enhance the bioavailability and decrease the toxicity Albumin is a promising nanocarrier endowed with biodegradable, biocompatible, non-toxic, and non-immunogenic properties
Plumbagin-Loaded Nanoemulsion Drug Delivery Formulation and Evaluation . . . Plumbagin showed potent anti-tumor activity in various tumor models, including breast cancer , Ehrlich ascites carcinoma , esophageal cancer , lung cancer , melanoma , ovarian cancer , promyelocytic leukemia , and prostate cancer [11–13]
Anti-Tumor Activity of Intravenously Administered Plumbagin Entrapped . . . Plumbagin, a natural naphthoquinone from the officinal leadwort, has recently been shown to exert promising anti-cancer effects However, its therapeutic use is hampered by its failure to specifically reach tumors after intravenous administration, without secondary effects on normal tissues