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The Genomic Applications in Practice and Prevention Network We believe that the development and availability of reliable and updated information on genomic applications in health care practice in the United States can be accelerated by a new collaborative initiative (Table 1) At the heart of the initiative is the convening of stakeholders interested in translating high impact, appropriately validated genomic applications into practice and prevention
The Evaluation of Genomic Applications in Practice and Prevention . . . The completion of the Human Genome Project has generated enthusiasm for translating genome discoveries into testing applications that have potential to improve health care and usher in a new era of “personalized medicine ” 1-4 For the last decade however, questions have been raised about the appropriate evidentiary standards and regulatory oversight for this translation process 5-10 The
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Avances genéticos y moleculares en el estudio de trastornos . . . - SciELO Correo electrónico: feescobarc@unal edu co Salamanca-Ortíz DN, Vergara-Vergara JY, Escobar-Córdoba F, Rodríguez-Gama Á, Caminos-Pinzón JE Avances genéticos y moleculares en el estudio de trastornos mentales rev fac med 2014;62:319-324
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Improving the efficiency and relevance of evidence-based . . . To provide an update on recent revisions to Evaluation of Genomic Applications in Practice and Prevention (EGAPP) methods designed to improve efficiency, and an assessment of the implications of whole genome sequencing for evidence-based recommendation development Improvements to the EGAPP approach include automated searches for horizon scanning, a quantitative ranking process for topic
The Genomic Applications in Practice and Prevention Network The authors describe the rationale and initial development of a new collaborative initiative, the Genomic Applications in Practice and Prevention Network The network convened by the Centers for Disease Control and Prevention and the National Institutes of Health includes multiple stakeholders from academia, government, health care, public health, industry and consumers
Full article: Strategies for Integrating Personalized Medicine into . . . PMC’s Healthcare Working Group PMC’s HWG is comprised of representatives from 49 organizations involved in healthcare delivery, including 19 academic health centers, 12 community healthcare systems, 16 healthcare delivery support organizations and two physician groups (Supplementary Material 1) PMC conducted a survey of the HWG regarding concerns and challenges related to the development
Population Sciences, Translational Research and the Opportunities and . . . Table 1 illustrates how selected population sciences can address scientific questions that can help close the translation gap of how genomic discoveries contribute to the cancer care continuum, both in healthy and affected persons in community and cancer care settings In primary care and population settings, knowledge of genes involved in cancer etiology can be used in risk assessment
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Improving the efficiency and relevance of evidence-based . . . The stages developed by EGAPP involve (i) quickly checking the quantity of evidence early in the process, (ii) using existing reviews, (iii) evaluating clinical validity before evaluating analytic validity and clinical utility, and (iv) using decision (scenario) modeling (Figure 1) This approach, to be described in detail in this article, does not obviate the need to perform the major task of
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