The clinical implications of selective IgA deficiency - PMC Highlights • Selective IgA deficiency is the most common primary immunodeficiency • It is associated with an increased risk of infections, allergic and autoimmune diseases, and rarely, malignancy • There is a risk of transfusion reactions due to the rare development of IgE against IgA in blood products • Treatment is supportive and directed at complications, with extremely rare use
Clinical significance of isolated IgE deficiency - UpToDate INTRODUCTION AND DEFINITION Selective immunoglobulin E (IgE) deficiency is defined as a significant decrease in the levels of IgE (<2 5 international units mL) in a patient whose other immunoglobulin levels, including IgG, IgG subclasses, and IgA levels, are normal
IgE deficiency: immunodeficiency, atopy malignancy Some IgE deficient patients have normal levels of other immunoglobulins (normal IgG, IgA, IgM), whereas others may have different associated immune abnormalities, ranging from isolated low levels in a single immunoglobulin isotype or subclass, to having Common Variable Immunodeficiency (CVID)
Selective IgA deficiency - Symptoms and causes - Mayo Clinic Overview Selective IgA deficiency is the lack of a disease-fighting antibody in the immune system called immunoglobulin A (IgA) People with this condition usually have typical levels of other immunoglobulins (im-u-no-GLOB-u-lins) An immunoglobulin is an antibody produced by immune system cells to fight bacteria, parasites and other agents that cause illness IgA antibodies circulate in the
Immunoglobulin A Deficiency - Johns Hopkins Medicine Immunoglobulin A (IgA) is a blood protein that's part of your immune system Your body makes IgA to help fight off sickness Having an IgA deficiency means that you have low levels or no immunoglobulin A in your bloodstream
Selective IgA deficiency - Immunodeficiency UK Selective immunoglobulin A deficiency (sIgAD) is the most common of the primary antibody deficiencies, afecting about 1 in 600 people It is not usually associated with bacterial infections but may be associated with autoimmune or allergic diseases The genetic causes of sIgAD are unclear People afected have very low or absent levels of one type of antibody, called immunoglobulin A (IgA), but
Low immunoglobulin E flags two distinct types of immune . . . The first, defined here as low IgE type 1, is associated with antibody deficiency (low IgG and IgA) and susceptibility to infection and or autoimmunity If a secondary cause of antibody deficiency is unlikely, these patients are often diagnosed as common variable immunodeficiency (CVID)