Comparison of Three Aspirin Formulations in Human Volunteers In patients with suspected ACS, the use of two 81-mg (162 mg) and possibly four 81-mg (324 mg) chewable tablets may be preferable to increase intraluminal surface area to aspirin and subsequent absorption and platelet inhibition
For CAD, what is the recommended dose of aspirin and why? Although there is general consensus that lower doses of aspirin are usually as effective as, and safer than, higher doses for most indications, there is much variability in prescribing patterns in part related to the lack of a robust evidence base for certain disease states
Anticoagulation and antiplatelet therapy in acute coronary syndromes During an ACS, the patient should receive one dose of aspirin 325 mg (the standard high-dose pill in the United States) This dose should be chewed, as buccal absorp-tion results in more rapid systemic effects 11 Thereafter, the patient should take 81 mg per day, continued indefinitely
Antiplatelet Therapy in Atherothrombotic Diseases: Similarities and . . . The JCS recommends a first dose of chewable aspirin tablets (162–324 mg) in naïve patients in whom ACS is clinically strongly suspected followed by a loading dose before primary percutaneous coronary intervention (PCI) then by a daily maintenance dose indefinitely unless contraindicated (JCS: COR I, LOE A) (Nakamura et al , 2020)