MAPK ERK pathway - Wikipedia The ERK pathway plays an important role of integrating external signals from the presence of mitogens such as epidermal growth factor (EGF) into signaling events promoting cell growth and proliferation in many mammalian cell types
ERK MAPK signalling pathway and tumorigenesis - PMC Extracellular signal-regulated kinase 1 2 (ERK) belongs to the mitogen-activated protein kinase (MAPK) family, which plays a role in signalling cascades and transmits extracellular signals to intracellular targets
Role of the Extracellular Signal-Regulated Kinase 1 2 . . . - Frontiers Extracellular signal-regulated kinase 1 2 (ERK 1 2) is a serine threonine protein kinase belonging to the mitogen-activated protein kinase (MAPK) family and is widely found in eukaryotic cells ERK 1 2 plays a key role in signal transduction from surface receptors to the nucleus
Extracellular Signal-Regulated Kinases: One Pathway, Multiple Fates - MDPI The ERK pathway is a key cell signaling system activated by physiological factors or oncogenic mutations, influencing different cell outcomes The protein kinases ERK1 and ERK2 (ERK) acting at the end of the pathway control whether cells grow, differentiate, age, or die
A guide to ERK dynamics, part 1: mechanisms and models Extracellular signal-regulated kinase (ERK) has long been studied as a key driver of both essential cellular processes and disease A persistent question has been how this single pathway is able to direct multiple cell behaviors, including growth, proliferation, and death