ERK 通路 | Cell Signaling Technology Explore the ERK pathway and its role in cell proliferation and survival Click here to read more about this critical signaling pathway
MAPK-ERK信号通路：药物研发的关键靶点 MAPK-ERK（Mitogen-Activated Protein Kinase-Extracellular Signal-Regulated Kinase）信号通路是MAPK家族中最经典的信号转导途径之一。 该通路主要由Ras、Raf、MEK和ERK等关键蛋白组成，通过级联磷酸化反应传递信号，最终调控基因表达和细胞功能。
Extracellular signal-regulated kinases - Wikipedia In the MAPK ERK pathway, Ras activates c-Raf, followed by mitogen-activated protein kinase kinase (abbreviated as MKK, MEK, or MAP2K) and then MAPK1 2 (below) Ras is typically activated by growth hormones through receptor tyrosine kinases and GRB2 SOS, but may also receive other signals
ERK MAPK signalling pathway and tumorigenesis - PMC ERK, a type of serine threonine protein kinase, is a signal transduction protein that transmits mitogen signals ERK is generally located in the cytoplasm; upon activation, ERK enters the nucleus and regulates transcription factor activity and gene expression
ERK signalling: a master regulator of cell behaviour, life and fate In this Review, we discuss the current understanding of this important class of kinases We begin with a brief overview of the structure, regulation, substrate recognition and subcellular localization of ERK1 and ERK2 We then systematically discuss how ERK signalling regulates six fundamental cellular processes in response to extracellular cues