MTHFR, SHMT and folinic acid? - Phoenix Rising ME CFS Forums It seemed to me that SHMT + + shouldn't be that big a problem because of this second pathway But, as Valentijn points out, there is research to say that it's a problem if you are C677T compromise There is no research on the combination I was interested in: SHMT and MTHFR A1296C If you come across any studies about it, please pass it on!
SHMT mutations and whether to address - Phoenix Rising ME CFS Forums SHMT is responsible for creating methylfolate and folinic acid, so it's possible you might be needing a bit of those Hmm, I am homozygous CC for SHMT1 rs9909104 Only 4% of Europeans have that And Watsonbell --- Valentijn, is there any reason to take both folinic acid and methylfolate as supplements?
It is known that virus infection induces massive production of free . . . Superoxide then undergoes spontaneous or enzymatic dismutation via superoxide dismutase (SOD) to generate hydrogen peroxide Although hydrogen peroxide is relatively stable, subsequent interactions with superoxide radicals and or transition metals such as Fe2+ or Cu2+ induce production of the highly toxic hydroxyl radical by Haber-Weiss and Fenton chemistry This radical, the hydroxyl radical
Immune system and ME CFS – key facts Posted by Tom Kindlon Whilst no definitive diagnostic test or biomarker has yet been identified for ME CFS, research shows multiple biological abnormalities, with strong evidence for immune system involvement Changes in the immune system may help explain why individuals with ME CFS
CBS and cofactors. Are CBS+ low in B6? - Phoenix Rising ME CFS Forums it’s important to address mutations in a precise sequence, especially for three critical mutations: SHMT, ACAT, and CBS I call these the First Priority mutations If you have SHMT or ACAT, please read about them and address them, if needed, first And then, if needed, go on to address the CBS mutation
23 me question | Phoenix Rising ME CFS Forums Some notes I had on VDR, SHMT: Serine hydroxymethyltransferase (SHMT1) is important for linked reactions The first is the conversion of tetrahydrofolate to 5,10-methylenetetrahydrofolate The second is the conversion of L-serine to glycine It also has a role in mediating the synthesis of dTMP and SAM
MTHFS defect (folinic acid intolerance) - request for genetic data A down-reg would cause a build up of folinic acid and thus inhibition of SHMT (and several other enzymes outside the methylation cycle as well) and create an intolerance to supplementation An up-reg can cause an increased turnover rate and depletion of cellular folate
23andme results | Phoenix Rising ME CFS Forums I don't see the result for SHMT, so I can't comment on that You have one First Priority mutation, which is CBS, along with some BHMTs which can add to CBS If you start on methyl supps and have a stress anxiety reaction or a head pressure, CBS could be expressed, causing these problems The Heartfixer page has good info on doing additional testing to see if CBS is expressed, and then a