JQ1 - Wikipedia JQ1 is a thienotriazolodiazepine and a potent inhibitor of the BET family of bromodomain proteins which include BRD2, BRD3, BRD4, and the testis-specific protein BRDT in mammals BET inhibitors structurally similar to JQ1 are being tested in clinical trials for a variety of cancers including NUT midline carcinoma [ 1 ]
JQ-1 (JQ1) | BET Inhibitor | MedChemExpress (+)-JQ-1 (JQ1) is a potent, specific, and reversible BET bromodomain inhibitor, with IC50s of 77 and 33 nM for the first and second bromodomain (BRD4(1 2)) (+)-JQ-1 also activates autophagy - Mechanism of Action Protocol
BET protein inhibitor JQ1 downregulates chromatin . . . - Nature Our results suggest that BET protein inhibitor JQ1 prohibits the malignant progression of GC cells by downregulating chromatin accessibility and inactivating RUNX2 NID1 signaling The clinical
Metabolism of JQ1, an inhibitor of bromodomain and extra . . . JQ1 is a small-molecule inhibitor of the bromodomain and extra terminal (BET) protein family that potently inhibits the bromodomain testis-specific protein (BRDT), which is essential for spermatogenesis