CMML Subtypes - Leukemia Lymphoma Society Most people diagnosed with chronic myelomonocytic leukemia (CMML) have one of three different subtypes of CMML Doctors classify CMML subtypes by the percentage of blast cells ("blasts") in the blood and bone marrow
CMML Subtypes, Stages, and Risk Groups - American Cancer Society If you are diagnosed with chronic myelomonocytic leukemia (CMML), doctors will want to learn more about your disease They will classify your CMML by its subtype, stage, and risk group This helps them understand your prognosis (outlook) and treatment options
Diagnosis and treatment of chronic myelomonocytic leukemia CMML is further classified into 3 subtypes according to the percentage of blasts in peripheral blood and the bone marrow It is also divided into the dysplastic and proliferative types according to the white blood cell (WBC) count in peripheral blood
Chronic myelomonocytic leukemia - Wikipedia WHO defined CMML has two main subsets, CMML-1 and CMML-2 CMML-1 is diagnosed if myeloblasts, monoblasts and promonocytes are <5% of peripheral blood and <10% of bone marrow CMML-2 is diagnosed if: Myeloblasts, monoblasts or promonocytes are 5-19% in blood, or
Chronic Myelomonocytic Leukemia - Leukemia Research Foundation The WHO classifies CMML into two subtypes based on the number of white blood cells in the blood Myelodysplastic CMML (MD-CMML): There are less than 13,000 white blood cells µL in the blood Myeloproliferative CMML (MP-CMML): There are 13,000 or more white blood cells µL in the blood
How I diagnose and treat chronic myelomonocytic leukemia Chronic myelomonocytic leukemia (CMML) is a myelodysplastic syndrome myeloproliferative overlap neoplasm characterized by sustained peripheral blood monocytosis and an inherent risk for transformation to acute myeloid leukemia (15-30% over 3-5 years)
Chronic Myelomonocytic Leukemia (CMML) and Juvenile Myelomonocytic . . . Subtypes In most healthy people, there are no blasts in the blood and fewer than 5 percent in the bone marrow The WHO categorizes CMML into the following three subtypes based on the percentage of blast cells found in the blood and bone marrow: CMML-0: Less than 2 percent blasts circulating in the blood and less than 5 percent blasts present
Chronic Myelomonocytic Leukemia (CMML) - Onkopedia In principle, two different subtypes are distinguished, the dysplastic subtype (more MDS-typical with more cytopenias, dysplasias as well as more frequent cytogenetic aberrations) and the proliferative subtype (more similarity to myeloproliferative neoplasms with more frequent splenomegaly, higher leukocyte counts with left shift and
Chronic Myelomonocytic Leukaemia (CMML) - Rare Cancers Australia Type 1 CMML is characterised by having between 2-4% of blasts (immature WBCs) in the blood and or between 5-9% of blasts in the bone marrow This subtype is characterised by the absence of Auer rods, which are long, needle-like structures that are present in abnormal cells under the microscope
Chronic Myelomonocytic Leukemia (CMML) - Cleveland Clinic Chronic myelomonocytic leukemia (CMML) is a rare type of blood cancer Having blood cancer means that there’s a problem with how your bone marrow — the spongy tissue inside your bones — makes blood cells With CMML, your bone marrow makes too many abnormal monocytes, a type of white blood cell
Chronic Myelomonocytic Leukemia: An Overview | MyLeukemiaTeam The other half of people have a CMML subtype that is more similar to an MPN (MP-CMML) This subtype comes with high levels of white blood cells Understanding your CMML subtype helps you know more about your prognosis (outlook) and understand which treatments may be most effective
Management recommendations for chronic myelomonocytic leukemia . . . WHO committees chose not to maintain the distinction between MD and MP CMML, but to divide CMML into two prognostic categories based on blast number: CMML-1 (blasts < 5% in blood and < 10% in BM) and CMML-2 (blasts 5–19% in blood and or 10–19% in BM)
How is Chronic Myelomonocytic Leukemia Staged and Classified? Does CMML Have Subtypes? CMML can be further categorized into two subtypes based on the white blood cell counts Myeloproliferative CMML (MP-CMML): has some characteristics that are similar to myeloproliferative neoplasms, the main one being a high white blood cell count (≥13 × 10^9 L)