Photoaging: UV radiation-induced inflammation and immunosuppression . . . Excessive exposure of the skin to UV radiation (UVR) triggers a remodeling of the immune system and leads to the photoaging state which is reminiscent of chronological aging Over 30 years ago, it was observed that UVR induced an immunosuppressive state which inhibited skin contact hypersensitivity
The role and safety of UVA and UVB in UV-induced skin erythema Different wavelengths of ultraviolet (UV) light cause skin damage through different mechanisms Minimal erythema dose (MED) is usually used to clinically evaluate skin sensitivity to ultraviolet radiation by inducing skin erythema using ultraviolet B (UVB) or ultraviolet A (UVA) + UVB
Loss of TRIM21 drives UVB-induced systemic inflammation by . . . - PubMed Methods: WT (C57BL 6) and Trim21- -mice were irradiated with UVB (100 mJ cm 2) on shaved dorsal region of the mice on consecutive days for 1 and 3 weeks, and UVB-induced local cutaneous manifestations and systemic inflammation in blood, spleen and kidney were examined by messenger RNA expression of inflammatory and type I IFN response genes
UVB-induced DNA damage, generation of reactive oxygen species, and . . . Ultraviolet (UV) radiation induces DNA damage, oxidative stress, and inflammatory processes in human keratinocytes resulting in skin inflammation, photoaging, and photocarcinogenesis The flavonoid luteolin is one of the most potent antioxidative plant polyphenols