Science︱加拿大蒙特利尔大学科研团队发现肥胖史诱发先天免疫系统的表观遗传改变并加剧神经炎症 - 知乎 2023年1月6日，来自蒙特利尔大学的 Przemyslaw Sapieha 团队在 Science 上发表了题为 “Past history of obesity triggers persistent epigenetic changes in innate immunity and exacerbates neuroinflammation” 的文章，通过转座酶可及的染色质（ATAC-seq）、ChIP-qPCR及流式分选等技术，揭示了早期饮食诱发的肥胖会引发 先天免疫系统 的重编程，这种表观改变即使在减肥或代谢正常后也持续存在。 硬脂酸 结合Toll样受体4（TLR4），可重塑染色质图谱并选择性地增强 激活蛋白 1（AP-1）结合位点的可及性。
Obesity induces epigenetic memory in innate immune cells Obesity substantially increases the risk of developing late-stage AMD, characterized by choroidal neovascularization (CNV), through the promotion of systemic inflammation, which can activate
Persisting Even After Weight Loss: Obesity Can Trigger Lasting . . . A recent study in mice has found that a history of obesity resulting from a high-fat diet can induce lasting changes in innate immunity that can promote inflammatory diseases These changes persist and continue to impact the body even after weight loss and a return to normal metabolism
Past obesity can trigger persistent epigeneti | EurekAlert! A history of obesity caused by a high-fat diet produces changes in innate immunity that can promote inflammatory disease – changes that persist even after weight loss and a return to
Long‐term impact of obesity: Unraveling adipose epigenetic memory Further analysis of epigenetic marks (H3K4me3, H3K27me3, H3K4me1, H3K27ac) and chromatin accessibility of already existent adipocytes prior to HFD exposure demonstrated widespread chromatin remodelling in adipocytes during obesity Many obesity‐induced changes persisted post‐weight loss
Past history of obesity triggers persistent epigenetic changes in . . . Article: Past history of obesity triggers persistent epigenetic changes in innate immunity and exacerbates neuroinflammation Age-related macular degeneration is a prevalent neuroinflammatory condition and a major cause of blindness driven by genetic and environmental fact
Obesity confers macrophage memory | Science - AAAS Oxidized low-density lipoprotein (LDL) particles, which occur at high concentrations in the circulation of people with obesity, induce an innate immune response and confer epigenetic memory in monocytes and myeloid precursors in bone marrow and spleen that influences inflammation and disease In this manner, myeloid cells from mice that are