PLEC Gene - GeneCards GeneCards PLEC (Plectin) is a Protein Coding gene Diseases associated with PLEC include Epidermolysis Bullosa Simplex 5A, Ogna Typeand Epidermolysis Bullosa Simplex 5B, With Muscular Dystrophy Among its related pathways are Type I hemidesmosome assemblyand Caspase-mediated cleavage of cytoskeletal proteins An important paralog of this gene
PLEC gene: MedlinePlus Genetics The PLEC gene provides instructions for making a protein called plectin Learn about this gene and related health conditions
Plectin - Wikipedia Plectin is a giant protein found in nearly all mammalian cells which acts as a link between the three main components of the cytoskeleton: actin microfilaments, microtubules and intermediate filaments [5] In addition, plectin links the cytoskeleton to junctions found in the plasma membrane that structurally connect different cells By holding these different networks together, plectin plays
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Entry - *601282 - PLECTIN; PLEC - OMIM - (OMIM. ORG) The PLEC1 gene encodes plectin-1, a 500-kD intermediate filament-binding protein that is one of the largest polypeptides known It was originally identified as a major component of intermediate filament preparations obtained from cultured cells (Pytela and Wiche, 1980) It is believed to provide mechanical strength to cells and tissues by acting as a crosslinking element of the cytoskeleton
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PLEC Gene: Functions, Diseases, and Research Learn about the PLEC gene, its role in cell adhesion and cytoskeletal integrity, and its association with various diseases like epidermolysis bullosa and muscular dystrophy Explore research on PLEC mutations and their implications
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PLEC plectin - NIH Genetic Testing Registry (GTR) - NCBI Clinical resource with information about PLEC, Autosomal recessive limb-girdle muscular dystrophy type 2Q, Biological, clinical and population relevance of 95 loci for blood lipids , Discovery and refinement of loci associated with lipid levels , Epidermolysis bullosa simplex 5B, with muscular dystrophy, Epidermolysis bullosa simplex 5C, with pyloric atresia, Epidermolysis bullosa simplex with