Pathology Outlines - Staging pTis: ductal carcinoma in situ, Padget disease, encapsulated papillary carcinoma and solid papillary carcinoma pTis (DCIS): ductal carcinoma in situ without invasive carcinoma pTis (Paget): Paget disease without invasive carcinoma pT1mi: tumor ≤ 1 mm pT1a: tumor > 1 mm but ≤ 5 mm pT1b: tumor > 5 mm but ≤ 10 mm
Pathology Outlines - Staging-bladder carcinoma pTis: carcinoma in situ pT1: invades lamina propria pT2a: invades inner half of muscularis propria pT2b: invades outer half of muscularis propria pT3a: microscopically invades perivesical tissue pT3b: macroscopically invades perivesical tissue pT4a: directly invades prostatic stroma, seminal vesicles, uterus or vagina
Pathology Outlines - Intramucosal carcinoma Malignant change confined to mucosa (considered pTis in AJCC staging); proper cutoff between high grade dysplasia and intramucosal carcinoma is not entirely clear
Pathology Outlines - Staging pTis: germ cell neoplasia in situ pT1: nonpure seminoma confined to testis tunica albuginea rete and no lymphovascular invasion (LVI) pT1a: seminoma < 3 cm confined to testis tunica albuginea rete and no LVI pT1b: seminoma ≥ 3 cm confined to testis tunica albuginea rete and no LVI
Pathology Outlines - Staging pTis pN0 pM0 G N A Stage IA: pT1a pN0 pM0 G1, GX Stage IB: pT1a pN0 pM0 G2 pT1b pN0 pM0 G1 - 2, GX Stage IC: pT1 pN0 pM0 G3 pT2 pN0 pM0 G1 - 2 Stage IIA: pT2 pN0 pM0 G3, GX Stage IIB: pT1 pN1 pM0 any G pT3 pN0 pM0 any G Stage IIIA: pT1 pN2 pM0 any G pT2 pN1 pM0 any G Stage IIIB: pT2 pN2 pM0 any G pT3
Pathology Outlines - Staging-penis pTis: carcinoma in situ pT1a: subepithelial invasion without lymphovascular invasion, perineural invasion or grade 3 pT1b: subepithelial invasion with lymphovascular invasion, perineural invasion or grade 3 pT2: invasion of corpus spongiosum pT3: invasion of corpus cavernosum
Pathology Outlines - Staging-parathyroid pTis: atypical parathyroid neoplasm (neoplasm of uncertain malignant potential) (see notes below) pT1: localized to the parathyroid gland with extension limited to soft tissue pT2: direct invasion into the thyroid gland pT3: direct invasion into recurrent laryngeal nerve, esophagus, trachea, skeletal muscle, adjacent lymph nodes or thymus
Pathology Outlines - Staging-carcinoma LAMN is reported as pTis(LAMN) if bound by muscularis propria, whereas HAMN would be pT1 or pT2 in the same situation, depending on whether submucosa or muscularis propria is involved Answer A is incorrect because both LAMN and HAMN can be pM1a