Ribozyme Structure: The Architecture of Catalytic RNA The initial discovery involved observing a self-splicing RNA molecule from the protozoan Tetrahymena thermophila, which could cut and rejoin its own structure without protein assistance This demonstrated that RNA is not just a passive messenger but an active participant in biochemical processes Levels of Ribozyme Architecture
Ribozyme - Wikipedia Ribozymes (ribo nucleic acid en zyme s) are RNA molecules that have the ability to catalyze specific biochemical reactions, including RNA splicing in gene expression, similar to the action of protein enzymes
Ribozymes (RNA enzymes) – Definition, Structure, Function, Types Ribozymes are catalytically active RNA molecules or RNA–protein complexes in which the RNA alone is responsible for the catalytic activity The term ribozyme simultaneously refers to enzymatic activity and ribonucleic acid nature Ribozymes are present in the genomes of all living kingdoms
Ribozymes: Catalytic Activity of RNA - Chemistry Notes Ribozymes are RNA molecules or RNA–protein complexes that are catalytically active, with the catalytic activity coming only from the RNA The name “ribozyme” describes both the ribonucleic acid nature and the enzymatic activity simultaneously
Ribozymes: the characteristics and properties of catalytic RNAs It appears that the RNA components of some, perhaps many, ribonucleoprotein complexes may have catalytic activity; for example, highly deproteinized ribosomes can still catalyze a peptidyl transfer reaction [3, 4], and nuclear mRNA splicing may be RNA-driven (see below) Moreover, new ribozymes are being generated, de novo, in the laboratory
Ribozymes and RNA Catalysis: Introduction and Primer Reactions catalysed by the known natural ribozymes observed in biology The biggest number carry out transesterification reaction (A), notably the nucleolytic ribozymes and the self-splicing introns RNaseP carries out a hydrolytic reaction to process tRNA molecules (B)
Ribozyme - SpringerLink They primarily catalyze various phosphoester transfer reactions, such as RNA splicing and other site-specific cleavage ligation of the RNA backbone Their closely related catalytic repertoires are achieved through a variety of unique structural scaffolds