Analytical method validation: A brief review Analytical method validation includes the determination of accuracy, precision, LOD, LOQ, linearity and range The results from method validation can be used to moderator the quality, reliability and consistency of analytical results, which is an integral part of any good analytical practice
Targeted test evaluation: a framework for designing . . . In diagnostic accuracy studies, study hypotheses are rarely pre-defined and sample size calculations are usually not performed, which may jeopardize scientific rigor and can lead to over-interpretation or “spin” of study findings In this paper, we propose a strategy for defining meaningful hypotheses in diagnostic accuracy studies
Quality Control: Enhancing Accuracy and Reliability By running internal control samples alongside patient samples, laboratories can assess the accuracy and precision of test results For example, in a biochemistry lab measuring glucose levels, running daily control samples at different concentration levels ensures the accuracy of the glucose assay
More Than Just Accuracy: A Novel Method to Incorporate . . . We developed a new model that multiple stakeholders (e g , clinicians, patients, researchers, test developers, industry, regulators, and health care funders) can use to visualize the multiple attributes of tests, the interactions that occur between these attributes, and their impacts on health outcomes
Introduction to diagnostic test accuracy studies - PubMed Researchers should analyse test accuracy studies using the appropriate methods, acknowledging the uncertainty of results and avoiding overstating conclusions and ignoring the clinical situation which should inform the trade-off between sensitivity and specificity
Binding the gap between experiments, statistics, and method . . . The most important AFOM include accuracy, precision, sensitivity, analytical sensitivity, prediction uncertainty, limit of detection (LOD), and limit of quantification (LOQ) All of them are used for the characterization and validation of a given methodology but also for method comparison
Systematic Reviews of Diagnostic Test Accuracy DTA systematic reviews summarise evidence on the accuracy of a single index test or compare the accuracy of two or more tests, including an investigation of reasons for heterogeneity (Leeflang 2014)