Therapeutic benefits of methylene blue on cognitive . . . - PubMed Methylene blue (MB) crosses the blood-brain barrier and at low doses serves as an electron cycler in the mitochondrial electron transport chain Previous studies implicate MB in both memory enhancement and neuroprotection
From Mitochondrial Function to Neuroprotection – An Emerging . . . Methylene blue improves sensorimotor phenotype and decreases anxiety in parallel with activating brain mitochondria biogenesis in mid-age mice Neurosci Res 2016;113:19–27 doi: 10 1016 j neures 2016 07 006
Methylene Blue “Avatar” Brain | Journal of Neuropathology . . . Methylene blue generates a clinically innocuous, self-limiting, but striking blue-green discoloration to the urine, skin, and mucosa of treated individuals as a by-product of its use (1, 7, 8) This systemic tissue discoloration is more well known than is discoloration of brain tissues, which, to our knowledge, has only been reported once
Can This Blue Chemical Really Boost Your Brain? Heres What . . . Studies in rodents have also found that methylene blue can protect the brain from damage from brain injury Other studies showed that methylene blue is useful in treating ischemic stroke in rats However, no research to date has examined whether it protects peoples' brains from traumatic brain injury or stroke
Methylene Blue in the Treatment of Neuropsychiatric . . . - PubMed In these studies, methylene blue produced an antidepressant and anxiolytic effect without risk of a switch into mania Long-term use of methylene blue in bipolar disorder led to a better stabilization and a reduction in residual symptoms of the illness
The Potentials of Methylene Blue as an Anti-Aging Drug - PMC MB can bypass Complex I III activity in mitochondria and diminish oxidative stress to some degree This review summarizes the recent studies on the applications of MB in treating age-related conditions, including neurodegeneration, memory loss, skin aging, and a premature aging disease, progeria
How Methylene Blue’s Antioxidants Can Slow Cognitive Decline As an electron transporter, Methylene Blue increases the number of ATPs produced by the brain’s mitochondria More available electrons also help to lower the concentration of undesirable free radicals
Methylene Blue Attenuates Traumatic Brain Injury-Associated . . . Here we show that immediate MB infusion (intravenous; 15–30 minutes after TBI) reduced cerebral edema, attenuated microglial activation and reduced neuroinflammation, and improved behavioral recovery after midline fluid percussion injury in mice