Mouse Models of Ulcerative Colitis: What Can They Really Tell Us? T-cell transfer colitis is a much newer model of colitis compared with IL10- - and DSS, but has quickly gained popularity In particular, this model is helpful for studying the role of Treg cells in intestinal inflammation (which should come as no surprise given the disease mechanism)
T Cell Transfer Model of Inflammatory Bowel Disease (IBD) Adoptive transfer of CD4+CD45RBhigh T cells (naive T cells, depleted of the Treg population) from healthy wild-type (WT) mice into syngeneic recipients that lack T and B cells induces a pancolitis and small bowel inflammation at 5-8 weeks following T cell transfer 2-7
Understanding the T Cell Transfer Model of Colitis The T cell transfer model primarily demonstrates how the transfer of activated T cells can induce colitis in immunodeficient mice This research has elucidated the crucial role T cells play in the pathogenesis of colitis
T Cell Transfer Model of Colitis - USTC Naïve T cells only or together with Treg cells isolated from different donors were transferred into immunodeficient Rag1- - mice and the disease progression was assessed by the loss of body
Induction of Colitis in Mice (T-Cell Transfer Model) Adaptive transfer of naïve T-cells from healthy wild-type mice into syngeneic recipients that lack T and B cells induces a pancolitis at 5–8 weeks following T-cell transfer Histopathological analysis of the colon obtained from mice with active disease reveals a transmural inflammation, epithelial cell hyperplasia, infiltration of leukocyte
Exploring the Adoptive T Cell Transfer Colitis Model for IBD The adoptive T cell transfer colitis model can be a powerful tool in translatable inflammatory bowel disease (IBD) research This widely acclaimed method utilizes precisely paired mouse strains to replicate human colitis in the laboratory, enhancing both basic research and the pursuit of novel treatments
Mouse Models of Acute and Chronic Colitis - Springer Nature DSS-induced intestinal inflammation in mice and T cell transfer colitis in SCID mice are most widely used and accepted models that can recapitulate the human diseases Here, we provide detailed protocols of these two mouse models of experimentally induced intestinal inflammation
446 The administration of JAK and TYK2 inhibitor successfully . . . Conclusions The T cell transfer IBD model was successfully established, presenting symptoms such as diarrhea, hematochezia, served body weight loss and increased colon density Treatment with Tofacitinib and BMS-986165 ameliorated the severity of T cell transfer-induced colitis in mice
Exploring Colitis through Dynamic T Cell Adoptive Transfer Models In this review, we summarize different CD4 + T cell adoptive transfer models of colitis, with a main focus on CD45RB hi T cell adoptive transfer model, and briefly describe several other models with their features, applications, strengths, and limitations