JMJD6 Gene - GeneCards | JMJD6 Protein | JMJD6 Antibody JMJD6 (Jumonji Domain Containing 6, Arginine Demethylase And Lysine Hydroxylase) is a Protein Coding gene Diseases associated with JMJD6 include Pontocerebellar Hypoplasia, Type 2F and Pancreatitis Among its related pathways are Metabolism of proteins and Chromatin organization
Role of the Epigenetic Modifier JMJD6 in Tumor Development and Regulation of Immune . . . JMJD6 is a member of the Jumonji (JMJC) domain family of histone demethylases that contributes to catalyzing the demethylation of H3R2me2 and or H4R3me2 and regulating the expression of specific genes JMJD6-mediated demethylation modifications are involved in the regulation of transcription, chromatin structure, epigenetics, and genome integrity
JMJD6 jumonji domain containing 6, arginine demethylase and lysine hydroxylase [ (human)] JMJD6 Is a Druggable Oxygenase That Regulates AR-V7 Expression in Prostate Cancer JMJD6 Regulates Splicing of Its Own Gene Resulting in Alternatively Spliced Isoforms with Different Nuclear Targets JMJD6 participates in the maintenance of ribosomal DNA integrity in response to DNA damage
Jumonji domain-containing protein 6 protein and its role in cancer The jumonji domain-containing protein 6 (JMJD6) is a Fe(II)- and 2-oxoglutarate (2OG)-dependent oxygenase that catalyses lysine hydroxylation and arginine demethylation of histone and non-histone peptides Recently, the intrinsic tyrosine kinase activity of JMJD6 has also been reported
Targeting JMJD6: A Novel Approach in Cancer Therapy? In this study, we confirmed the critical role of JMJD6 in a NSCLC cell line and a liver cancer cell line Using CRISPR Cas9, we replaced the endogenous JMJD6 promoter with a doxycycline-regulated promoter, creating conditional JMJD6 cells We will examine the effects of JMJD6 depletion in these cells and assess
Role of the Epigenetic Modifier JMJD6 in Tumor Development and Regulation . . . - Frontiers JMJD6 is a member of the Jumonji (JMJC) domain family of histone demethylases that contributes to catalyzing the demethylation of H3R2me2 and or H4R3me2 and regulating the expression of specific genes JMJD6-mediated demethylation modifications are involved in the regulation of transcription, chromatin structure, epigenetics, and
JMJD6 Shapes a Pro-tumor Microenvironment via ANXA1-Dependent Macrophage Polarization . . . The vast majority of the enriched biological pathways in JMJD6 KO MCF7 involved inflammatory mechanisms, including IFNα and IFNγ response, and TNFα signaling via NF-κB , suggesting that loss of JMJD6 could affect the immune composition of tumor microenvironment (TME) and therefore the inflammatory response