PTPN11 - Tyrosine-protein phosphatase non-receptor type 11 - Homo . . . This entry describes 3 isoforms produced by Alternative splicing Q06124-2 This isoform has been chosen as the canonical sequence All positional information in this entry refers to it This is also the sequence that appears in the downloadable versions of the entry
RCSB PDB - 2SHP: TYROSINE PHOSPHATASE SHP-2 Crystal structure of the tyrosine phosphatase SHP-2 The structure of the SHP-2 tyrosine phosphatase, determined at 2 0 angstroms resolution, shows how its catalytic activity is regulated by its two SH2 domains
SHP2 General Information | Sino Biological Included within the latter category are 2 closely related mammalian intracellular PTPases whose sequences encode 2 tandem SRC homology 2 (SH2) domains that are located at the amino-terminal side of a single PTPase catalytic domain
PTPN11 - Wikipedia PTPN11 encodes SHP2, a ubiquitously expressed protein tyrosine phosphatase that plays an important role in regulating cell signaling pathways, most notably the RAS MAPK cascade, which controls cell proliferation, differentiation, migration, and survival
SHP-2 tyrosine phosphatase in human diseases - PMC SHP-2, a ubiquitously expressed Src homology 2 (SH2) domain-containing protein tyrosine phosphatase (PTP), plays a critical role in physiology and disease SHP-2 has been clearly demonstrated to be an important molecule in various cytoplasmic signal transduction pathways
SHP-2 (Src Homology Region 2-containing Protein Tyrosine Phosphatase-2) The structure of SHP-2 includes two N-terminal SH2 domains followed by a protein tyrosine phosphatase (PTP) domain and a C-terminal tail In its inactive state, the N-terminal SH2 domain blocks the catalytic site, creating an auto-inhibited conformation
Sequence Specificity of SHP-1 and SHP-2 Src Homology 2 Domains In this work, a peptide library has been designed and screened against the four SH2 domains of SHP-1 and SHP-2 to systematically assess the sequence specificity at pY+4 to pY+6 positions