一波三折：Nature Medicine再发文，证实贺建奎敲除的CCR5 . . . 2019年12月24日，顶级医学期刊 Nature Medicine 杂志发表题为：No statistical evidence for an effect of CCR5-Δ32 on lifespan in the UK Biobank cohort 的文章【1】。该文章称，没有统计证据表明 CCR5-∆32的纯和突变 对寿命有影响。这一结论与今年6月份 Nature Medicine 发表的称 CCR5-∆32的纯和突变 会导致个体 全因死亡率 增加
Legacy of a magic gene- CCR5- ∆ 32: From discovery to . . . - PubMed The discovery of the 32-bp deletion allele of the chemokine receptor gene CCR5 showed that homozygous carriers display near-complete resistance to HIV infection, irrespective of exposure Algorithms of molecular evolutionary theory suggested that the CCR5-∆32 mutation occurred but once in the last millennium and rose by strong selective pressure relatively recently to a ~10% allele frequency