Using VST plugins in Reason 12. 5 - Reason Studios About using VST plugins in Reason Here are some general notes regarding VST compatibility in Reason: Reason 12 5 and later supports 64-bit VST3 and 64-bit VST2 (2 4) plugins Both Windows and Mac VSTs are supported Multitimbrality in VSTs is currently not supported - only one MIDI channel per VST can be played back at a time If you are using a multitimbral VST it will only receive on MIDI