CRIg CRIg + macrophages contribute to the ability of the liver to filter gut microbial DNA encapsulating EVs, whereas obesity elicits a decreased CRIg + macrophage population and subsequently facilitates the spread of microbial DNA–containing EVs into various metabolic tissues
CRIg - ScienceDirect CRIg is a type 1 transmembrane Ig superfamily member that is found in two alternatively spliced forms: CRIg (L) that encodes both V and C 2 -type terminal Ig domains and CRIg (S) which encodes only a single V-type domain
Complement Receptor of the Immunoglobulin Superfamily CRIg The N-terminal domain of CRIg belongs to the IgV immunoglobulin-like domain, and the CRIg domain contains two β sheets CRIg binds C3b and C3c in the same way, with the same affinity
CRIg: A Macrophage Complement Receptor Required for . . . Here we report the identification and characterization of a Complement Receptor of the Immunoglobulin superfamily, CRIg, that binds complement fragments C3b and iC3b CRIg expression on Kupffer cells is required for efficient binding and phagocytosis of complement C3-opsonized particles
Improving Therapeutic Efficacy of a Complement Receptor by . . . CRIg is a recently discovered complement receptor expressed on a subpopulation of tissue resident macrophages CRIg binds C3b, iC3b, and C3c but not the parent molecule C3 and efficiently clears complement-coated particles from the circulation (8)