4-Methanesulfonyloxybutanol: Hydrolysis of Busulfan The half-life of this first-order reaction in aqueous solution at 37° was determined to be approximately 12 min at pH 3 as well as at pH 7 4 From the present data, it is concluded that 4-methanesulfonyloxybutanol is unlikely to be responsible for the biological action of busulfan
Busulfan - StatPearls - NCBI Bookshelf Busulfan specifically works by having a hydrolysis reaction occur with the 2 easily displaced methanesulfonate groups located on opposite ends of a butane chain within the drug's chemical structure
4-Methanesulfonyloxybutanol: Hydrolysis of Busulfan Experiments to provide r)-methanesulfonyloxybutanol(III) by par- tial saponification of busulfan, as well as total hydrolysis under acidic and alkaline conditions, were followed by NMR spectros- copy
Clarifying Busulfan Metabolism and Drug Interactions to Support New . . . Hydrolysis of these groups produces highly reactive, positively charged carbonium ions that alkylate and damage DNA molecules [18] More precisely, Bu reacts with guanine molecules through a nucleophilic substitution reaction (S N 2), forming DNA intra- or interstrand cross-links [19]
4-Methanesulfonyloxybutanol: Hydrolysis of Busulfan - Journal of . . . The half-life of this first-order reaction in aqueous solution at 37° was determined to be approximately 12 min at pH 3 as well as at pH 7 4 From the present data, it is concluded that 4-methanesulfonyloxybutanol is unlikely to be responsible for the biological action of busulfan
Degradation of busulfan in aqueous solution - ScienceDirect The second-order reaction rate constant for the reaction of busulfan with hydroxide ion (Table 2) was determined from the equation: Kobs = Ko + KOH- [OH-] (2) by plotting Kobs versus OH- concentration (Fig 3)
Degradation of busulfan in aqueous solution - PubMed The reactivity of HPO (4) (-2) was six times higher than the reactivity of H (2)PO (4) (-1) towards busulfan The hydrolysis products were identified as tetrahydrofuran and methanesulphonic acid by nuclear magnetic resonance spectroscopy