Mechanisms of Kidney Injury in Lupus Nephritis – the Role of . . . In lupus nephritis, IL-6 deposition is localized to mesangial cells and podocytes and is also present alongside immune deposits in the glomerulus Although the mechanisms through which IL-6 secretion is induced in resident renal cells has yet to be fully elucidated, we have demonstrated that binding of anti-dsDNA antibodies to annexin II in
Lupus Nephritis: Immune Cells and the Kidney Microenvironment Lupus nephritis (LN) is the most common major organ manifestation of the autoimmune disease SLE (lupus), with 10% of those afflicted progressing to ESKD The kidney in LN is characterized by a significant immune infiltrate and proinflammatory cytokine milieu that affects intrinsic renal cells and is, in part, responsible for the tissue damage
Pathogenic cellular and molecular mediators in lupus nephritis Chromatin is a central autoantigen driving adaptive immune system activation in SLE M W Mesangial cells are key contributors to the fibrotic damage seen in the lupus nephritis glomerulus J
The Pathogenesis of Lupus Nephritis - PMC - PubMed Central (PMC) Lupus nephritis has been associated with intraglomerular cell apoptosis in which nucleosomes are released in apoptosis and then associate with glomerulus basement membranes, which potentially allows these apoptotic nucleosomes to be both the inducer and target for the autoantibodies causing lupus nephritis in SLE Immune electron microscopy
Intracapillary immune complexes recruit and activate slan . . . Glomerular monocytes have been reported in human lupus nephritis type III and IV, and their presence was associated with poor prognosis when found at repeated biopsies (11, 35–37) In line with this, mouse models of lupus nephritis demonstrated a proinflammatory role for monocytes activated by ICs (21, 38) However, the exact definition of
What is damaging the kidney in lupus nephritis? | Nature . . . Initiation of inflammation by immune complexes Lupus nephritis is initiated in most cases by the glomerular deposition of IgG and complement Rarely, nephritis can occur in the absence of immune