Transcriptomics-based analysis of acetate and propionate transport and . . . These findings illustrate the capacity of Y lipolytica to coordinate carbon and nitrogen metabolism during carboxylate utilisation, such as acetate and propionate, offering insights to guide the optimisation of microbial oil production from renewable feedstocks
Dissecting carbon metabolism of Yarrowia lipolytica type strain W29 . . . This model was used to delineate cellular metabolism, analyze gene essentiality and predict biochemicals production yields on various carbon sources, indicating that it is a high-quality model for Y lipolytica and will be a powerful tool for cell factory design in the future
Regulatory effects of carbon and nitrogen nutrition on lipid . . . In addition to pH, carbon sources, nitrogen sources, and their ratios play indispensable roles in the growth and lipid synthesis of Y lipolytica The carbon source, which determines both VFA composition and concentration, is closely associated with lipid yield and substrate inhibition effects
Metabolic engineering for increased lipid accumulation in Yarrowia . . . In this review, we highlight the newest strategies for increasing lipid accumulation using metabolic engineering and summarize the research advances on the overaccumulation of lipids in Y lipolytica Finally, perspectives for future engineering approaches are proposed
Insights into the methanol utilization capacity of Y. lipolytica and . . . In this work, we investigated the potential of Y lipolytica to utilize methanol as a sustainable carbon source for bioproduction in silico and experimentally We found that a simple overexpression of a heterologous methanol dehydrogenase allowed Y lipolytica to use methanol as a co-substrate