The Biology of the Glucocorticoid Receptor: New Signaling Mechanisms in . . . Advances in our understanding of glucocorticoid signaling have uncovered a variety of mechanisms that contribute to reduced glucocorticoid responsiveness, including increased expression of the GRβ and GRα-D isoforms, changes in GR phosphorylation, and homologous down-regulation of the receptor
Glucocorticoid receptor signaling in health and disease In this review, we provide an update on glucocorticoid receptor signaling and highlight the role of GR signaling in physiological and pathophysiological conditions in the major organ systems in the human body
Glucocorticoid receptor signaling: intricacies and therapeutic . . . Abstract The glucocorticoid receptor (GR) is a major nuclear receptor (NR) drug target for the treatment of inflammatory disorders and several cancers Despite the effectiveness of GR ligands, their systemic action triggers a plethora of side effects, limiting long-term use
Glucocorticoid receptor signaling in health and disease Glucocorticoid receptor (GR) signaling On binding glucocorticoids, the cytoplasmic GR undergoes a conformational change, becomes hyperphosphorylated (P), dissociates
Glucocorticoid receptor signaling in health and disease In this review, we provide an update on glucocorticoid receptor signaling and highlight the role of GR signaling in physiological and pathophysiological conditions in the major organ systems in the human body
Mechanisms of glucocorticoid receptor signaling during . . . - PubMed In this review, we discuss the molecular mechanisms underlying GR inhibition of inflammatory responses, with an emphasis on repression of NF-kappaB and AP-1 and their respective signaling pathways Glucocorticoids are among the most widely prescribed anti-inflammatory drugs