Amyloid formation as a protein phase transition - Nature Amyloid formation is a transition between the dilute solution phase of a protein and a solid β-sheet-rich aggregated phase that occurs through nucleation-and-growth processes Uncontrolled
Protein Phase Transition: From Biology Towards New Protein Materials We identify the role of ATP and RNA in triggering the nucleation and growth of the protein-rich droplets, as well as in maintaining the protein dense phase in the liquid state These results reveal molecular mechanisms that cells have plausibly developed to accurately control the reversible assembly and the biophysical properties of P-bodies
Protein Phase Separation: A New Phase in Cell Biology Accumulating evidence points to a key role for phase transitions in human diseases associated with protein aggregation, and to the misregulation of membraneless organelles in disease Understanding the physical principles and molecular interactions behind protein phase separation could inspire novel biomaterials
LLMs predict protein phases - Nature Methods Proteins normally exist in soluble form but can undergo a phase transition to a dense liquid phase via liquid–liquid phase separation (LLPS) or to solid aggregates such as amyloids
Protein Phase Separation as a Stress Survival Strategy - PMC We propose that protein phase separation is an evolutionary conserved feature of proteins that cells harness to regulate adaptive stress responses and ensure survival in extreme environmental conditions
Protein Phase Transitions in Health and Disease Our lab aims at understanding how genetic changes between individuals can or cannot result in disease by quantifying the impact mutations have on protein aggregation and toxicity