The DNA methyltransferase family: a versatile . . . - Nature The DNA methyltransferase (DNMT) family comprises a conserved set of DNA-modifying enzymes Recent studies have increased our understanding of how DNMT activity is regulated and revealed that, in
Neuronal DNA Methyltransferases: Epigenetic Mediators between . . . The Neuronal Phenotype of Dnmt Mouse Mutants DNMTs are broadly involved in embryo development and the targeted mutation of Dnmt1 or Dnmt3a and -3b results in early embryonic lethality (Li and others 1992; Okano and others 1999) Transgenic Dnmt mice with conditional alleles for gene deletion have provided spatial and temporal control of DNMT
Tissue-specific roles of de novo DNA methyltransferases Genomic imprinting, characterized by parent-of-origin specific expression of a few dozens of genes, is regulated by various epigenetic mechanisms, including DNA methylation A hallmark of these genes is a regulatory region called the imprinting control region (ICR), which is methylated on the silenced allele and devoid of methylation on the
Fine-tuning of gene expression through the Mettl3-Mettl14 . . . The result is a dynamic balance between transcriptional activity and RNA stability, ensuring subtle control of gene expression The link evidenced here between epigenetics and epitranscriptomics is part of a larger gene-expression-regulating network
DNMT3a Downregulation Ttriggered Upregulation of GABAA . . . DNA methylation, a key epigenetic mechanism regulating gene expression, is catalyzed by DNMTs, enzymes that convert cytosine to 5-mC In cancer biology, research has highlighted the central role of epigenetic dysregulation in carcinogenesis, positioning epigenetic modifications as promising therapeutic targets [ 5 ]