Pedigree investigation, clinical characteristics, and . . . We aimed to compare the clinical characteristics of patients with germline and somatic TET2 mutations in haematological diseases and to analyse whether germline TET2 mutations have a family aggregation and tumour predisposition
TET2 mutation is an independent favorable prognostic factor . . . In multivariate analysis adjusted for age, International Prognostic Scoring System, and transfusion requirement, the presence of TET2 mutation remained an independent factor of favorable prognosis (hazard ratio, 5 2; 95% CI, 1 6-16 3; P = 005)
Familial myeloid malignancies with germline TET2 mutation In line with these observations, TET2 mutations have been shown to cooperate with JAK2 V617F to generate MPN while SRSF2 disruption in a context of TET2 haploinsufficiency promotes
TET2 mutations contribute to adverse prognosis in acute . . . Multivariate analysis revealed TET2 mutations as independent risk factor for overall survival (OS) in both the total AML cohort (OR = 1 649, p = 0 009) and in the 2022 ELN intermediate-risk cohort (HR = 1 967, p = 0 05)
Age-Associated TET2 Mutations: Common Drivers of Myeloid . . . They also found that the presence of additional mutations such as in ASXL1 indicate poorer prognosis , while another group found that overall survival is greater in patients with clonal TET2 mutations in the absence of ASXL1 mutations