Myeloid Malignancy Precursor Conditions: What Fellows Need to . . . The development of a myeloid malignancy such as MDS or acute myeloid leukemia (AML) involves a progression through several precursor disease states (Figure 1 and Table) The earliest identifiable development in this sequence is clonal hematopoiesis of indeterminate potential (CHIP)
What Are Precursor Blood Conditions and How Are They Treated? Clonal cytopenia of undetermined significance, (CCUS) is marked by a low blood count and a set of blood cells carrying a genetic mutation It can place individuals at risk for myelodysplastic syndrome or acute myeloid leukemia
Signs and Symptoms of Acute Myeloid Leukemia (AML) Many signs and symptoms of AML are the result of low levels of normal blood cells This happens when the leukemia cells crowd out the normal blood-making cells in the bone marrow As a result, people don't have enough normal red blood cells, white blood cells, and blood platelets
The Absolute Monocyte Count at Diagnosis Affects Prognosis in . . . A low absolute monocyte count (AMC) has been shown to be of prognostic value in MDSs in two studies [11,12] In other chronic myeloid diseases, such as Philadelphia chromosome-negative myeloproliferative neoplasms, a higher AMC is associated with adverse disease features and inferior prognosis [13,14]
The White Blood Cell and Differential Count - Clinical . . . Leukocyte alkaline phosphatase is found in the more mature cells of the myeloid series, bands and neutrophils It is useful for the differential diagnosis between CML (chronic myelocytic leukemia) where it is low, from leukemoid reactions, where it is normal