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- Extracellular cGAMP is a cancer cell-produced immunotransmitter . . .
2’3’-cyclic GMP-AMP (cGAMP) is an intracellular second messenger that is synthesized in response to cytosolic double-stranded DNA and activates the innate immune STING pathway Our previous discovery of its extracellular hydrolase ENPP1 hinted at the existence of extracellular cGAMP
- 3,3-cGAMP | 99. 84%(HPLC) | In Stock | STING activator - Selleckchem. com
3',3'-cGAMP (3',3'-cyclic GMP-AMP, Cyclic GMP-AMP, cGAMP) activates the endoplasmic reticulum (ER)-resident receptor stimulator of interferon genes (STING), thereby inducing an antiviral state and the secretion of type I IFNs
- ABCC1 transporter exports the immunostimulatory cyclic dinucleotide cGAMP
Cyclic GMP-AMP (cGAMP) is an “immunotransmitter” that can be imported into cells to activate antiviral responses, but how cGAMP exits cells is currently unknown Maltbaek et al identify ABCC1 as an active cGAMP exporter that modulates STING-dependent immunity
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- cGAMP the travelling messenger - Frontiers
In this review, we describe the fast-paced discoveries of the mechanisms by which 2’3’-cGAMP can be transported We further highlight the diseases where they are important and detail how this change in perspective can be applied to vaccine design, cancer immunotherapies and treatment of cGAS-STING associated disease
- Pivotal Roles of cGAS-cGAMP Signaling in Antiviral Defense . . . - Science
Cyclic GMP-AMP synthase (cGAS) was recently identified as a sensor of cytosolic DNA Li et al (p 1390, published online 29 August) now use knockout mice to provide genetic evidence that, in multiple cell types, cGAS is the primary DNA sensor required for the type I interferon response in vivo
- cGAMP the travelling messenger - PMC
2’3’-cGAMP is a key molecule in the cGAS-STING pathway This cyclic dinucleotide is produced by the cytosolic DNA sensor cGAS in response to the presence of aberrant dsDNA in the cytoplasm which is associated with microbial invasion or cellular
- Extracellular cGAMP is a cancer-cell-produced . . . - Nature
2′3′-Cyclic GMP-AMP (cGAMP) is an intracellular second messenger that is synthesized in response to cytosolic double-stranded DNA and activates the innate immune STING pathway Our
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