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- Targeted drug delivery systems for atherosclerosis
The promotion of inflammation in atherosclerosis typically involves a combination of anti-cytokine antibodies and cytokine secretion inhibitors, which can lead to increased systemic toxicity due to the lack of tissue-specific targeting
- Advancements in dual-targeting nanoparticle strategies for enhanced . . .
In this review, we discuss the pathological process of atherosclerosis and examine the progress made in its treatment using rationally designed nanoparticles over recent decades We critically evaluate the limitations of single-targeting strategies and explore potential areas for improvement
- Targeting immune cell recruitment in atherosclerosis - Nature
In this Review, the authors discuss the receptors, ligands and interactors that regulate immune cell recruitment in atherosclerosis, describe mechanisms that promote the resolution of
- Novel mechanisms and therapeutic targets in atherosclerosis . . .
This review based on the ESC William Harvey Lecture in Basic Science 2022 highlights recent experimental and translational progress on the therapeutic targeting of the inflammatory components in atherosclerosis, introducing novel strategies to limit side effects and to increase efficacy
- Nanoparticle Drug Delivery Systems for Atherosclerosis: Precision . . .
This review systematically explores the pathophysiological mechanisms underlying atherosclerosis and examines recent advances in nanoparticle drug delivery systems (NDDSs) tailored for atherosclerosis treatment NDDS has many advantages in this setting
- Targeted drug delivery systems for atherosclerosis - PubMed
Based on this, this review discusses the potential role of targeted drugs in the treatment of atherosclerosis It also focuses on their clinical efficacy in anti-atherosclerosis treatment and their ability to provide more precise therapeutic approaches
- OxLDL-Targeted Chimeric Antigen Receptor T Regulatory Cells Reduce . . .
Background: Cardiovascular disease caused by atherosclerosis is responsible for 18 million deaths annually, highlighting a significant need for new medical therapies, especially for patients who are not eligible for percutaneous interventions Atherosclerosis is driven by the accumulation of low-density lipoprotein (LDL) and the formation of foam cells, accompanied by oxidative stress and the
- T Cell-Targeting Nanotherapies for Atherosclerosis
In this Review, we outline the role of T cells in atherosclerosis, examine current nanotherapeutic strategies for targeting T cells and modulating their differentiation, and provide perspectives for the development of nanoparticles specifically tailored to target T cells for the treatment of atherosclerosis
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