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- Beta Asarone - an overview | ScienceDirect Topics
Beta-asarone is a strong fat-soluble substance with a small molecular weight that can pass through the BBB easily and be come widely distributed without target regions in the brain Grounded on these characteristics, we found that beta-asarone has significant pharmacological effects on the CNS
- Molecular Mechanisms and Therapeutic Potential of α- and β-Asarone in . . .
Recently, our research has identified α- and β-asarone, found in high levels in the rhizomes of the medicinal plant Acorus calamus (L ), as important secondary metabolites with potential therapeutic benefits for the treatment of AD, PD, and other neurological disorders
- Beta-asarone, a major component of Acorus tatarinowii Schott . . .
Acorus tatarinowii Schott is native to Central Asia, North America and Eastern Europe [2] β-Asarone (cis-2,4,5-trimethoxy-1-allyl phenyl), which can affect the central nervous system (CNS) [3 - 6], is a major component of Acorus tatarinowii Schott β-Asarone could pass the blood–brain barrier (BBB) and thus enter the brain [7]
- Asarone - an overview | ScienceDirect Topics
Beta-asarone inhibits neuronal apoptosis via the CaMKII CREB Bcl-2 signaling pathway in PC12 cells and AβPP PS1 mice (Wei et al , 2013) β−asarone attenuates inflammatory cytokines including tumor necrosis factor-α (TNF-α), interleukin-1ß (IL-1ß), and IL-6 production
- β2-adrenoreceptors control human skin microvascular reactivity
Topical α1- and α2-adrenoreceptor (ADRA1 and 2) agonists are effective in alleviating permanent vasodilation and facial erythema associated with rosacea by inducing skin vasoconstriction
- Molecular Mechanisms and Therapeutic Potential of α- and β-Asarone in . . .
Current research indicates that α- and β-asarone exert neuroprotective effects by mitigating oxidative stress, abnormal protein accumulation, neuroinflammation, neurotrophic factor deficit, and promoting neuronal cell survival, as well as activating various neuroprotective signalling pathways
- Beta-Asarone Reduces Autophagy in a Dose-Dependent Manner and . . .
These results indicate that beta-asarone can attenuate brain ischemia-reperfusion-induced autophagy and brain injury in a dose-dependent manner, which implies that autophagy inhibition is likely to be a new pathway of beta-asarone to protect against brain injury
- Beta Asarone - an overview | ScienceDirect Topics
Beta-asarone inhibits neuronal apoptosis via the CaMKII CREB Bcl-2 signaling pathway in PC12 cells and AβPP PS1 mice (Wei et al , 2013) β−asarone attenuates inflammatory cytokines including tumor necrosis factor-α (TNF-α), interleukin-1ß (IL-1ß), and IL-6 production It also significantly reduced Beclin-1, LC3B and increased anti
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