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- Correlation of the COMT Val158Met polymorphism with latitude and a . . .
Indeed, the COMT*L (the site-present allele, Met, that encodes the low-activity enzyme) and COMT*H (the site-absent allele, Val, that encodes the high-activity enzyme) alleles show significant world-wide variation, as reported by a study surveying allele frequencies of this polymorphism in a global sample of populations (Palmatier et al , 1999
- COMT OESTROGEN | DNAlysis - dnalife. academy
COMT Val158Met (472 G>A) Allele Frequency reports global frequencies of 36 9% and 44 91% respectively for the variant A-allele (NIH) A meta-analysis from Rai et al (2017) reported that the frequency of the A (Met) allele vary greatly among the populations studied: frequency of A (Met) allele is reported as 56% in American, 50% in European
- VCV000017591. 15 - ClinVar - NCBI - National Center for Biotechnology . . .
The global minor allele frequency calculated by the 1000 Genomes Project The minor allele at this location is indicated in parentheses and may be different from the allele represented by this VCV record The COMT Val158Met polymorphism affects the response to entacapone in Parkinson's disease: a randomized crossover clinical trial
- COMT Val Met, stressful life events and externalizing behaviors in . . .
The effects of COMT Val158Met on behavior and cognition is potentially explained by this inverted U-shape [58, 75, 76] Moreover, an inverse relationship between brain norepinephrine levels and aggressive behaviors have been first demonstrated by rats [77], and later confirmed in human studies [78] Thus the potential lower norepinephrine
- Get to know a gene: COMT - GeneSight
The first two studies (n=187) found better outcomes in patients with the Val allele 108,109 However, three subsequent studies (n=627) found no association between the Val158Met polymorphism and response to amphetamines 110-112 Two of these studies (n=581) 110,111 attempted to replicate the results of the two earlier studies (n=187) 108,109
- Correlation of the COMT Val158Met polymorphism with latitude and a . . .
variation, as reported by a st udy surveying allele frequencies of this polymorphism in a global sample of populations (Palmatier et al , 1999) Palmatier and colleagues showed that Europeans have the highest frequency of the COMT*L allele, while the COMT*H allele is much more common in populations in all other parts of the world Their study also
- Prevalence of COMT Val158Met polymorphism in Eastern UP population
The aim of the present study was to determine the frequency of COMT Val158Met polymorphism in scheduled caste (SC) population of Jaunpur district Total 100 healthy unrelated subjects belonging to SC, between the age group of 18 to70 years were randomly selected for the present study 3 ml blood samples were collected from each subject
- Role of the COMT gene Val158Met polymorphism in mental disorders: A review
The effect of the COMT gene Val158Met polymorphism is stronger in some ethnic groups than in others COMT Val Met allele frequencies differ across the world Palmatier et al [38] genotyped 1314 individuals from 30 different populations for the COMT gene Val158Met polymorphism in the first global survey Clearly, there is higher heterozygosity
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