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- Ganciclovir: Uses, Interactions, Mechanism of Action - DrugBank Online
Mechanism of action Ganciclovir's antiviral activity inhibits virus replication This inhibitory action is highly selective as the drug must be converted to the active form by a virus-encoded cellular enzyme, thymidine kinase (TK)
- PharmGKB summary: Acyclovir Ganciclovir Pathway - PMC
This review describes the metabolism, transport, and mechanism of action of ACV and GCV with a view to decipher the existing interpatient variability, and it supports these drugs being considered as candidates for use in personalized medicine
- What is the mechanism of Ganciclovir? - synapse. patsnap. com
Ganciclovir is a synthetic analog of 2'-deoxy-guanosine, a building block of DNA Its mechanism of action primarily involves inhibiting viral DNA synthesis, which is essential for the replication of the CMV virus
- Mechanism of Action - DailyMed
Mechanism of Action: Ganciclovir is an acyclic nucleoside analogue of 2'-deoxyguanosine that inhibits replication of herpes viruses Ganciclovir has been shown to be active against cytomegalovirus (CMV) and herpes simplex virus (HSV) in human clinical studies
- UpToDate
MECHANISM OF ACTION Ganciclovir (9-[(1,3,-dihydroxy-2-propoxy)methyl] guanine, or DHPG) is an acyclic analog of the nucleoside guanosine The drug is converted intracellularly to ganciclovir 5'-monophosphate by a viral kinase, which is encoded by the cytomegalovirus (CMV) gene UL97 during infection
- Ganciclovir (Systemic): Dosage, Mechanism Onset of Action, Half-Life . . .
Mechanism of Action Ganciclovir is phosphorylated to a substrate which competitively inhibits the binding of deoxyguanosine triphosphate to DNA polymerase resulting in inhibition of viral DNA synthesis Pharmacokinetics Pharmacodynamics Distribution
- Gancyclovir: Chemical Structure, Mechanism of Action, Uses Side Effects
Mechanism of Action: Ganciclovir is a nucleoside analogue antiviral agent that primarily works against cytomegalovirus (CMV) and, to a lesser extent, herpes simplex viruses (HSV) and varicella-zoster virus (VZV)
- A review: Mechanism of action of antiviral drugs - PMC
An analysis of the action mechanism of known antiviral drugs concluded that they can increase the cell’s resistance to a virus (interferons), suppress the virus adsorption in the cell or its diffusion into the cell and its deproteinisation process in the cell (amantadine) along with antimetabolites that causes the inhibition of nucleic acids
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