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- Complex Karyotype, but Not Isolated TP53 mutation, Predicts . . .
Stratifying the impact of TP53 aberration showed that biallelic TP53 (del(17p) and TP53 mutation) had the poorest outcome, followed by del(17p) alone, whereas TP53 mutation alone did not affect OS compared to patients without TP53 aberration (5-year OS 83%, 84 9%, 92 5%, and 95 7%, respectively) Additionally, complex karyotype (CK) (p<0 001
- Monosomal karyotype and chromosome 17p loss or TP53 mutations . . .
In MDS, mono-allelic TP53 mutations associate with more favorable disease features (including less frequent complex karyotype and better OS) than multi-hit TP53 mutations The role of TP53 mutations under consideration of their allelic state remains to be established
- TP53 mutation status divides myelodysplastic syndromes with . . .
Complex karyotype MDS patients have a high frequency of TP53 mutations which are associated with specific clinical features Of the 359 MDS patients with CK shared with the IWG for MDS Prognosis
- TP53 mutation defines a unique subgroup within complex . . .
A subset of myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) show complex karyotype (CK), and these cases include a relatively high proportion of cases of therapy-related myeloid neoplasms and TP53 mutations We aimed to evaluate the clinicopathologic features of outcome of 299 AML a …
- TP53 alterations in acute myeloid leukemia with complex . . .
Chromosomal abnormalities are found in approximately 55% of adult patients with acute myeloid leukemia (AML) and are among the most important independent prognostic factors 1–3 AMLs exhibiting 3 or more acquired chromosome aberrations in the absence of chromosomal rearrangements listed in the World Health Organization (WHO) 2008 category “AML with recurrent genetic abnormalities” are
- TP53 Mutations in Acute Myeloid Leukemia: Still a Daunting . . .
Prognostic Impact of TP53 Mutations in AML The European Leukemia net (ELN) guidelines represent probably the most established source for evaluating risk of resistance and classifying patients into “favorable,” “intermediate,” and “unfavorable” groups according to cytogenetic and molecular mutations detected in leukemic cells
- The complex karyotype in hematological malignancies: a . . .
The complexity of a karyotype is related to its negative prognostic impact Therefore, the prognostic risk of complexity has to be determined for each malignancy
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