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  • Physiology, Serotonin - StatPearls - NCBI Bookshelf
    Central nervous system: Serotonin is widely known for its effect on mood, but it also plays a role in memory, anger, fear, appetite, stress, addiction, sexual pleasure, sleep, pain perception, cerebral vascular tone, and central respiratory drive
  • Multiple roles of serotonin in pain control mechanisms . . .
    Among monoamine neurotransmitters, serotonin (5-HT) is known to play complex modulatory roles in pain signaling mechanisms since the first reports, about forty years ago, on its essentially pro-nociceptive effects at the periphery and anti-nociceptive effects when injected directly at the spinal cor …
  • An Association of Serotonin with Pain Disorders and Its . . .
    One of the most studied neurotransmitters related to pain disorders is serotonin Estrogen can modify serotonin synthesis and metabolism, promoting a general increase in its tonic effects
  • Serotonin in Pain and Pain Control - ScienceDirect
    In pain processing and modulation, serotonin (5-hydroxtryptamine, 5-HT) has excitatory (hyperalgesic) and inhibitory (analgesic) actions, depending on the site of action, the cell type and the type of receptor
  • Serotonin in pain and analgesia | Molecular Neurobiology
    The purpose of this article is to summarize recent findings on the role of serotonin in pain processing in the peripheral nervous system Serotonin (5-hydroxtryptamine [5-HT]) is present in central and peripheral serotonergic neurons, it is released from platelets and mast cells after tissue injury, and it exerts algesic and analgesic effects
  • Serotonin-Norepinephrine Reuptake Inhibitors for Pain Control . . .
    However, extensive data support a role for the monoamine neurotransmitters, serotonin and norepinephrine, in the modulation of pain Experiments with animal models of pain indicate that noradrenergic interventions, and to a lesser extent serotonergic interventions, reduce pain-related behavior


















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