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- IL-37 isoform D downregulates pro-inflammatory cytokines expression in . . .
In addition, IL-37d is detected in mesenchymal stem cells, such as UCMSCs Mesenchymal stem cells are involved in immune regulation For example, graft-versus-host disease (GVHD) can be successfully treated by MSCs administrated 39, 40 Thus, our results suggest that IL-37d is an important regulator of immunity
- Interleukin-37 regulates innate immune signaling in human and mouse . . .
IL-37 is an anti-inflammatory cytokine that inhibits innate signaling in diverse cells by signaling through SIGIRR Despite the strong expression of SIGIRR by IEC, few studies have examined
- Cytokines in Graft-versus-Host Disease Free - American Association of . . .
Graft-versus-host disease (GVHD) is a phenomenon almost unique to allogeneic bone marrow transplantation (BMT) whereby lymphocytes are introduced and permitted to engraft and proliferate within an immunocompromised host
- IL-37 dampens immunosuppressive functions of MDSCs via metabolic . . .
In the current study, we found that IL-37 expression significantly inhibited HCC cell proliferation and promoted apoptosis by arresting the cell cycle to G2 M phase in both murine and human HCC cell lines
- Current Understanding of IL-37 in Human Health and Disease
IL-37 is a recently discovered cytokine in the IL-1 family exerting broad protective effects on inflammatory diseases, autoimmune diseases, and cancer Immune and non-immune cells produce the IL-37 precursor upon pro-inflammatory stimuli
- Cytokines in GVHD and GVL - ScienceDirect
Transplant recipients lacking IL-22 demonstrate increased GVHD pathology in the intestines and liver, increased injury to the intestinal stem cell (ISC) compartment, and increased GVHD-related mortality in both MHC-mismatched and mHA-mismatched experimental mouse models
- Targeting Cytokines in GVHD Therapy - PMC - PubMed Central (PMC)
Proinflammatory cytokines released by activated immune cells including T cells lead to the onset of GVHD T cell depletion (TCD) is an effective approach for GVHD prevention Several immune suppressive drugs are also used to treat GVHD
- Interleukin-2 and Regulatory T Cells in Graft-versus-Host Disease
Interleukin-2 is critical for Treg cell growth, survival, and activity We hypothesized that low-dose interleukin-2 could preferentially enhance Treg cells in vivo and suppress clinical
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