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- Clinical effects of curcumin in enhancing cancer therapy: A systematic . . .
Curcumin exerts its anti-cancer effects through a variety of mechanisms Curcumin inhibits and suppresses the proliferation of a wide range of cancer cells, which exerts its effects by reducing the modulation of anti-apoptotic gene products, activating caspase, and upregulating cancer-suppressive genes such as P53 [22,23,24] Recent studies
- Curcumin and Cancer (PDQ®) - NCI - National Cancer Institute
Extensive research over the past two decades suggests that curcuminoids, the active ingredient in turmeric (C longa), interfere with multiple cell signaling pathways, providing support for the potential role of curcumin in modulating cancer development and progression
- Potential Anticancer Properties and Mechanisms of Action of Curcumin
Curcumin inhibits the STAT3 and NF-κB signaling pathways, which play key-roles in cancer development and progression Also, inhibition of Sp-1 and its housekeeping gene expressions may serve as an important hypothesis to prevent cancer formation, migration, and invasion
- Curcumin in Cancer Therapy: Mechanisms, Delivery Systems . . . - IntechOpen
This chapter provides a comprehensive overview of curcumin’s mechanisms of action in cancer therapy, focusing on its effects on cell proliferation, apoptosis, metastasis, and inflammation Curcumin exerts its anticancer effects through various signaling pathways, including the suppression of NF- kappa;B, JAK STAT3, and PI3K Akt
- Effects and Mechanisms of Curcumin for the Prevention and . . . - MDPI
Inhibition of cancer cell migration and invasion may be one of the most essential anticancer mechanisms of curcumin A study found that curcumin reduced breast cancer MCF-7 cell migration, as shown in the wound healing assay
- Potential Mechanisms of Action of Curcumin for Cancer Prevention . . . - ijbs
Curcumin, a hydrophobic polyphenol extracted from turmeric, has gained increasing attention due to its powerful anticancer properties Curcumin can inhibit the growth, invasion and metastasis of various cancers The anticancer mechanisms of curcumin have been extensively studied
- Discovery of Novel Curcumin Derivatives as Potential Anti-Lung Cancer . . .
The antitumor activity and the underlying mechanism of six novel curcumin derivatives (F1–F6) were evaluated in lung cancer cells F5 was found to be the most potent derivative (IC 50 = 13 67 μM) compared to curcumin (IC 50 = 40 93 μM), with significant differences via MTT assay
- Curcumin: A review of anti-cancer properties and therapeutic activity . . .
In SAS oral cancer cells, curcumin induced the promoter activity of insulin-like growth factor binding protein-5 (IGFBP-5) and CCAAT enhancer-binding protein alpha (C EBPalpha), proteins involved in the suppression of head and neck cancers
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