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- Apolipoprotein E - Wikipedia
Apolipoprotein E (Apo-E) is a protein involved in the metabolism of fats in the body of mammals A subtype is implicated in Alzheimer's disease and cardiovascular diseases [5] It is encoded in humans by the gene APOE Apo-E belongs to a family of fat-binding proteins called apolipoproteins
- APOE Gene Test: What It Is, How It Works Results
An APOE gene test is a type of genetic test that identifies which variant of the apolipoprotein E (APOE) genotype you have Having certain APOE genotypes may mean you have an increased risk of Alzheimer’s disease
- What is APOE, how is it related to Alzheimers disease, and should I . . .
Apolipoprotein E, or APOE, is a gene that comes in several forms, or alleles: APOE2, APOE3, and APOE4 Everyone carries 2 copies of this gene, one from each of their biological parents Which APOE type you have, differentially impacts your risk for Alzheimer’s disease
- Alzheimers: Is it in your genes? - Mayo Clinic
As with APOE, variants of these genes are risk factors, not causes That means that having one of these genetic variants might increase the risk of Alzheimer's But not everyone with one of these variants will get Alzheimer's disease Researchers continue to learn more about Alzheimer's disease
- ApoE in Alzheimer’s disease: pathophysiology and therapeutic strategies . . .
There are three predominant APOE alleles in humans; the ε2 (APOE2), ε3 (APOE3), and ε4 (APOE4) alleles which confer varying levels of disease risk
- APOE gene: MedlinePlus Genetics
The APOE gene provides instructions for making a protein called apolipoprotein E Learn about this gene and related health conditions
- APOE-Targeted Therapeutics for Alzheimers Disease
Apolipoprotein E (APOE) is the major lipid transport protein in the brain Produced primarily by astrocytes and microglia, it delivers cholesterol and other lipids for membrane repair, synaptic maintenance, and immune regulation Through interactions with specific lipid receptors, APOE maintains neuronal and vascular health The APOE ε4 allele (APOE4), carried by approximately one-quarter of
- Multifaceted roles of APOE in Alzheimer disease
For the past three decades, apolipoprotein E (APOE) has been known as the single greatest genetic modulator of sporadic Alzheimer disease (AD) risk, influencing both the average age of onset and
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