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- Astrocytes, the Gatekeepers of Norepinephrine Signaling in the Brain . . .
However, astrocyte adrenergic signaling did not drive the initial sprint The scientists think that this excitatory phase was likely due to NE directly eliciting signaling through excitatory β-adrenergic receptors on neurons, as this arousal signal transmits more rapidly than the inhibitory pathway does in astrocytes
- Alleviating symptoms of neurodegenerative disorders by astrocyte . . .
News: Astrocyte Receptor Suppresses Neurotoxic Lipids, Preserves Neurons; It’s exciting to see advancements in research that could lead to innovative clinical interventions This study provides the first evidence of a regulatory role of TMEM164 in astrocyte activation within the nervous system
- Astrocyte Reactivity: Opposing States Emerge | ALZFORUM
A cocktail of cytokines triggers at least two opposing astrocyte reactions that balance each other Controlled by STAT3, one churns out IL-6; the other unleashes interferons A core group of transcriptional regulators oversees a diversity in astrocyte reactions across different disorders
- Astrocyte reactivity influences amyloid-β effects on tau . . . - ALZFORUM
Astrocyte transcriptomic changes along the spatiotemporal progression of Alzheimer's disease 2022 Dec 07 10 1101 2022 12 03 518999 (version 1) bioRxiv Serrano-Pozo A, Gómez-Isla T, Growdon JH, Frosch MP, Hyman BT
- GPCR signaling gates astrocyte responsiveness to neurotransmitters and . . .
GPCR signaling gates astrocyte responsiveness to neurotransmitters and control of neuronal activity Science 2025 May 15;388(6748):763-768 Epub 2025 May 15 PubMed Recommends Please login to recommend the paper Comments Shane Liddelow NYU Langone; Posted: 28 May 2025; News: Astrocytes, the Gatekeepers of Norepinephrine Signaling in the Brain
- Astrocyte transcriptomic changes along the spatiotemporal progression . . .
This was an ambitious study using single-nucleus RNA-Seq to characterize astrocyte heterogeneity across five brain regions in 32 donors who spanned the spectrum of Alzheimer’s disease neuropathology The authors’ analysis of normal brains revealed astrocyte heterogeneity across the neocortex
- Astrocytes Mount Complex Responses to AD. They Change Over Time
In the November 11 Nature Neuroscience, the researchers detailed seven astrocyte subtypes that changed in different ways in response to plaques and tangles Two states had not been previously described: One, rich in growth factors, waned with increasing pathology; another, reflecting stress, went into overdrive in the late stages of tangle
- Border Surprise: Glia Limitans Astrocytes Sit on Brain Surface
Some previous studies have also found astrocyte cell bodies on the brain’s surface (Feig and Haberly, 2011; Falcone et al , 2021), and one reported these cells were myocilin+ (Wu et al , 2017) Human Brain, Too In postmortem brain samples, myocilin+ astrocytes (purple) cover the brain surface and extend processes into the parenchyma
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