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- B-cell activating factor - Wikipedia
BAFF is the natural ligand of three nonconventional tumor necrosis factor receptors named BAFF-R (BR3), TACI (transmembrane activator and calcium modulator and cyclophilin ligand interactor), and BCMA (B-cell maturation antigen), all of which have differing binding affinities for it
- Baltic-American Freedom Foundation
Continuing a longstanding American commitment to the Baltic region, the Baltic-American Freedom Foundation (BAFF) mission is to deepen the ties between and among Estonia, Latvia, Lithuania, and the United States through programs of education and exchange centering on economic growth and democratic values
- BAFF: A fundamental survival factor for B cells - Nature
BAFF is a survival factor for B cells that controls B-cell maturation BAFF -deficient mice lack mature B cells BAFF supports the survival of immature T2 B cells and, possibly, mature B
- The BAFF APRIL system: Emerging functions beyond B cell biology and . . .
In this review, we provide the latest views on additional roles of the BAFF system in health and diseases, as well as an update on BAFF and autoimmunity, with particular focus on current clinical trials
- B cell activating factor (BAFF): Structure, functions . . . - PubMed
The B cell activating factor (BAFF), or B lymphocyte stimulator (BLyS), is a B cell survival factor which supports autoreactive B cells and prevents their deletion BAFF expression is closely linked with autoimmunity and is enhanced by genetic alterations and viral infections
- B cell activating factor (BAFF): Structure, functions, autoimmunity and . . .
Belimumab, an anti-BAFF antibody, is the only biologic agent so far approved for SLE therapy The B cell activating factor (BAFF), or B lymphocyte stimulator (BLyS), is a B cell survival factor which supports autoreactive B cells and prevents their deletion
- BAFF receptor - Wikipedia
BAFF receptor (B-cell activating factor receptor, BAFF-R), also known as tumor necrosis factor receptor superfamily member 13C (TNFRSF13C) and BLyS receptor 3 (BR3), is a membrane protein of the TNF receptor superfamily which recognizes BAFF, an essential factor for B cell maturation and survival
- BAFF signaling in health and disease - PubMed
BAFF is a critical cytokine supporting the survival of mature naïve B cells, acting through the BAFFR receptor Recent studies show that BAFF and BAFFR are also required for the survival of memory B cells, autoimmune B cells as well as malignant chronic lymphocytic leukaemia (CLL) cells
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